2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. NVP-DFF332

NVP-DFF332  (Synonyms: HIF-2α-IN-8)

製品番号: HY-148860 純度: 99.31%
COA 取扱説明書 Technical Support

HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity.

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NVP-DFF332

NVP-DFF332 構造式

CAS 番号 : 2734922-78-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 968 在庫あり
Solution
10 mM * 1 mL in DMSO USD 968 在庫あり
Solid
1 mg $300 在庫あり
5 mg $880 在庫あり
10 mg $1400 在庫あり
25 mg $2520 在庫あり
50 mg $3780 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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NVP-DFF332 関連抗体

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HIF-1α HIF PHD1

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製品説明

HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].

IC50 & Target

IC50: 9 nM (HIF2α SPA); 37 nM (HIF2α iScript); 246 nM (HIF2α HRE RGA)[1]
体内実験

HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)[1]
Dosage: 30 mg/kg
Administration: P.o.; started 34 days post tumor inoculation; daily for 21 days
Result: Inhibited the tumor growth.
分子量

441.73

分子式

C17H11ClF7N3O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 250 mg/mL (565.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2638 mL 11.3191 mL 22.6383 mL
5 mM 0.4528 mL 2.2638 mL 4.5277 mL
10 mM 0.2264 mL 1.1319 mL 2.2638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.31%

COA (254 KB) HNMR (290 KB) LCMS (103 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2638 mL 11.3191 mL 22.6383 mL 56.5957 mL
5 mM 0.4528 mL 2.2638 mL 4.5277 mL 11.3191 mL
10 mM 0.2264 mL 1.1319 mL 2.2638 mL 5.6596 mL
15 mM 0.1509 mL 0.7546 mL 1.5092 mL 3.7730 mL
20 mM 0.1132 mL 0.5660 mL 1.1319 mL 2.8298 mL
25 mM 0.0906 mL 0.4528 mL 0.9055 mL 2.2638 mL
30 mM 0.0755 mL 0.3773 mL 0.7546 mL 1.8865 mL
40 mM 0.0566 mL 0.2830 mL 0.5660 mL 1.4149 mL
50 mM 0.0453 mL 0.2264 mL 0.4528 mL 1.1319 mL
60 mM 0.0377 mL 0.1887 mL 0.3773 mL 0.9433 mL
80 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
100 mM 0.0226 mL 0.1132 mL 0.2264 mL 0.5660 mL
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NVP-DFF332 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-DFF3322734922-78-0HIF-2α-IN-8HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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製品名:
NVP-DFF332
製品番号:
HY-148860
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