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Cat. No.: HY-146204

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HIV-1 capsid inhibitor 1

HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor with an EC₅₀ value of 3.13 µM. HIV-1 capsid inhibitor 1 shows antiviral activities.

For research use only. We do not sell to patients.

CAS No.: 2396382-78-6
Formula: C₃₄H₃₁FN₆O₄
Molecular Weight:606.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

HIV-1 capsid inhibitor 1 Chemical Structure

CAS No.: 2396382-78-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

HIV-1 capsid inhibitor 1 is a potent HIV-1 Capsid inhibitor with an EC₅₀ value of 3.13 µM. HIV-1 capsid inhibitor 1 shows antiviral activities^[1].

IC₅₀ & Target^[1]

HIV-1

3.13 μM (EC₅₀)

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
TZM	CC₅₀	>16.48 μM Compound: 6a-9	Cytotoxicity against in human TZM-bl cells assessed as reduction in cell viability measured after 2 days by cell titre glo luminiscent cell viability assay Cytotoxicity against in human TZM-bl cells assessed as reduction in cell viability measured after 2 days by cell titre glo luminiscent cell viability assay	[PMID: 32066010]

In Vitro

HIV-1 capsid inhibitor 1 (compound 6a-9) shows anti-HIV activity in TZM-bl cells with an EC₅₀ value of 3.13 µM and an CC₅₀ value of >16.48 µM^[1].
HIV-1 capsid inhibitor 1 shows antiviral activities in the early and late event of the HIV-1 NL4-3 lifecycle with IC₅₀s of 8.18, 0.32 µM, respectively^[1].
HIV-1 capsid inhibitor 1 shows metabolic stability in human liver microsomes and plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2396382-78-6
Molecular Weight 606.65
Formula C₃₄H₃₁FN₆O₄
SMILES

COC1=CC=C(C=C1)N(C)C([C@@H](NC(CN2C=C(N=N2)C3=CC=CC=C3NC(C4=CC=CC=C4F)=O)=O)CC5=CC=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun L, et al. Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities. Eur J Med Chem. 2020 Mar 15;190:112085. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HIV-1 capsid inhibitor 1

All HIV Isoforms