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Cat. No.: HY-149991

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HIV-1 inhibitor-56

HIV-1 inhibitor-56 (compound 12126065) is a potent HIV-1 non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-56 has antiviral activity against wild-type HIV-1 in TZM cells with an EC₅₀ value of 0.24 nM. HIV-1 inhibitor-56 penetrates the blood-brain barrier.

For research use only. We do not sell to patients.

CAS No.: 2952530-45-7
Formula: C₂₂H₁₄ClN₇O₂S
Molecular Weight:475.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HIV-1 inhibitor-56 Chemical Structure

CAS No.: 2952530-45-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Neuron	EC₅₀	>10 μM Compound: 12126065	Neurotoxicity in mouse primary neurons assessed as loss of MAP-2 intensity incubated for 48 hrs by imaging analysis Neurotoxicity in mouse primary neurons assessed as loss of MAP-2 intensity incubated for 48 hrs by imaging analysis	[PMID: 37130343]
TZM	CC₅₀	4.8 μM Compound: 12126065	Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability by MTS assay Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability by MTS assay	[PMID: 37130343]
TZM	CC₅₀	4.8 μM Compound: 12126065	Cytotoxicity against human TZM-bl cells assessed as reduction in viability incubated for 48 hrs by MTT assay Cytotoxicity against human TZM-bl cells assessed as reduction in viability incubated for 48 hrs by MTT assay	[PMID: 37130343]

Chemical Information

CAS No. 2952530-45-7
Molecular Weight 475.91
Formula C₂₂H₁₄ClN₇O₂S
SMILES

N#C/C=C/C1=CC2=C(C(S(N3C(N)=NC(NC4=CC=C(C#N)C(Cl)=C4)=N3)(=O)=O)=CC=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lane T, et, al. N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor. J Med Chem. 2023 May 11;66(9):6193-6217. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HIV-1 inhibitor-56

All HIV Isoforms