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Cat. No.: HY-10891

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HIV-1 inhibitor-61

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC₅₀ of 0.07 nM in NL4-3 wt MT-4 cells.

For research use only. We do not sell to patients.

CAS No.: 1114507-62-8
Formula: C₂₄H₂₄F₂N₂O₂S
Molecular Weight:442.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HIV-1 inhibitor-61 Chemical Structure

CAS No.: 1114507-62-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC₅₀ of 0.07 nM in NL4-3 wt MT-4 cells^[1].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
TZM	CC₅₀	31.1 μM Compound: 1	Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability after 2 days by WST-1 assay Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability after 2 days by WST-1 assay	[PMID: 26898379]

Chemical Information

CAS No. 1114507-62-8
Molecular Weight 442.52
Formula C₂₄H₂₄F₂N₂O₂S
SMILES

O=C1NC(SC[C@H]2[C@H](C3=CC=C(OC)C=C3)C2)=NC([C@@H](C4=C(F)C=CC=C4F)C)=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marco Radi, et al. Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. J Med Chem. 2009 Feb 12;52(3):840-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HIV-1 inhibitor-61

All HIV Isoforms