Hydrouracil-4-benzazimide-7-NH2
Hydrouracil-4-benzazimide-7-NH2 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Hydrouracil-4-benzazimide-7-NH2 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- CAS No.: 2250288-89-0
- Formula: C12H11N5O3
- Molecular Weight:273.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2250288-89-0
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Molecular Weight 273.25
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Formula C12H11N5O3
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SMILES
O=C1NC(=O)C(N2N=NC=3C=C(N)C=CC3C2=O)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)