TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

Also Known as LFG3; RECS1; MST100; PP1201; MSTP100

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64114

About TMBIM1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,274,197-218,292,503 (from NCBI)

This gene has 23 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues.

Summary

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM1 Products (10)

mRNA Protein Name
NM_001321427.2 NP_001308356.1 protein lifeguard 3 isoform 1
NM_001321428.2 NP_001308357.1 protein lifeguard 3 isoform 1
NM_001321429.2 NP_001308358.1 protein lifeguard 3 isoform 1
NM_001321430.2 NP_001308359.1 protein lifeguard 3 isoform 1
NM_001321432.2 NP_001308361.1 protein lifeguard 3 isoform 1
NM_001321433.2 NP_001308362.1 protein lifeguard 3 isoform 1
NM_001321435.2 NP_001308364.1 protein lifeguard 3 isoform 1
NM_001321436.2 NP_001308365.1 protein lifeguard 3 isoform 1
NM_001321438.2 NP_001308367.1 protein lifeguard 3 isoform 2
NM_022152.6 NP_071435.2 protein lifeguard 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables death receptor binding IDA
IDA: Inferred from direct assay
21107705 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Fas signaling pathway IMP
IMP: Inferred from mutant phenotype
21107705 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
21107705 GOA
involved in negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
21107705 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
21107705 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
16607040 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
16607040 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMBIM1 Protein Structure

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (97 - 307)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

protein lifeguard 3

  • transmembrane BAX inhibitor motif-containing protein 1

TMBIM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra
TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra
TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra
TMBIM1 Q969X1 B3GALNT2 Homo sapiens Q8NCR0
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Validated Y2H
32296183
Intra
TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Y2H Array
32296183
Intra
TMBIM1 Q969X1 GGT6 Homo sapiens Q6P531
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 GGT6 Homo sapiens Q6P531
Y2H Array
32296183
Intra
TMBIM1 Q969X1 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra
TMBIM1 Q969X1 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
TMBIM1 Q969X1 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
TMBIM1 Q969X1 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
TMBIM1 Q969X1 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14618 TMBIM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMBIM1 VGNC VGNC:66232
Rattus norvegicus TMBIM1 RGD RGD:1359409
Canis familiaris TMBIM1 VGNC VGNC:49789
Macaca mulatta TMBIM1 VGNC VGNC:79392
Mus musculus TMBIM1 MGD MGI:1916910
Bos taurus TMBIM1 VGNC VGNC:35915
Others TMBIM1 NCBI