1. Metabolic Enzyme/Protease
  2. HIV Integrase
  3. Integrase-LEDGF/p75 allosteric inhibitor 1

Integrase-LEDGF/p75 allosteric inhibitor 1 

Cat. No.: HY-147653
Handling Instructions

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432.

For research use only. We do not sell to patients.

Integrase-LEDGF/p75 allosteric inhibitor 1 Chemical Structure

Integrase-LEDGF/p75 allosteric inhibitor 1 Chemical Structure

CAS No. : 1431738-14-5

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Description

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].

IC50 & Target

EC50: 3.9 nM (NL432)[1]

In Vivo

Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) has moderate metabolic stability (HLM MS = 59%, RLM MS = 61%), exhibits good clearance (CLt = 6.99 mL/min/kg) and good bioavailability (F = 36%) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

579.75

Formula

C33H41NO6S

CAS No.
SMILES

CC1=CC=C(C=C1C)C2=C(C(C3=CC=C4OCCCC4=C3C)=C(C(C)=C2NS(C)(=O)=O)C(C(O)=O)OC(C)(C)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
Integrase-LEDGF/p75 allosteric inhibitor 1
Cat. No.:
HY-147653
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