1431738-14-5
Chemical Structure
Integrase-LEDGF/p75 allosteric inhibitor 1
- CAS No.: 1431738-14-5
- Formula:C33H41NO6S
- Molecular Weight:579.75
IUPAC Name: 2-(tert-butoxy)-2-(2,3',4',5-tetramethyl-3-(5-methylchroman-6-yl)-6-(methylsulfonamido)-[1,1'-biphenyl]-4-yl)acetic acid
InChIKey: JCQVWFOOYKCORR-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1C)C2=C(C(C3=CC=C4OCCCC4=C3C)=C(C(C)=C2NS(C)(=O)=O)C(C(O)=O)OC(C)(C)C)C
Biological Activity: Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432[1].
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Integrase-LEDGF/p75 allosteric inhibitor 1 | Integrase-LEDGF/p75 allosteric inhibitor 1 (Compound 31h) is an orally active integrase-LEDGF/p75 (IN-LEDGF/p75) allosteric inhibitor. Integrase-LEDGF/p75 allosteric inhibitor 1 inhibits HIV-1 DNA integration and shows antiviral activity with an EC50 of 3.9 nM against HIV-1 recombinant molecular clone NL432. | |||||||||||||||||||||
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