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Cat. No.: HY-W700788

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Isobutyryl-L-carnitine chloride-d₆

Isobutyryl-L-carnitine chloride-d₆ is the d₆-labeled Isobutyryl-L-carnitine chloride (HY-113165A). Isobutyryl-L-carnitine chloride is a biomarker. Isobutyryl-L-carnitine chloride is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine chloride is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine chloride is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine chloride can be used in research on renal cell carcinoma.

For research use only. We do not sell to patients.

Formula: C₁₁H₁₆D₆ClNO₄
Molecular Weight:273.79

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Isobutyryl-L-carnitine chloride-d₆ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 6920-31-6
Molecular Weight 273.79
Formula C₁₁H₁₆D₆ClNO₄
SMILES

O=C(C[C@@H](OC(C(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C[N+](C)(C)C)O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo L, et al. A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker. Analytical chemistry. 2020 Jul 21;92(14):9745-9754.

[2]. Cao C, et al. Metabonomic analysis of toxic action of long-term low-level exposure to acrylamide in rat serum. Human & experimental toxicology. 2018 Dec;37(12):1282-1292. [Content Brief]

[3]. Oto J, et al. Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study. Journal of proteomics. 2020 Apr 30;218:103723.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Isobutyryl-L-carnitine chloride-d₆

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Biological Activity
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Chemical Information
Purity & Documentation
References

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Isobutyryl-L-carnitine chloride-d6

All Endogenous Metabolite Isoforms

Biological Activity

Description

IC50 & Target

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Isobutyryl-L-carnitine chloride-d6 Related Classifications

HY-W700788 Related Classifications

Bioz

Keywords

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