Tradd - TNFRSF1A-associated via death domain Gene

Also Known as 9130005N23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71609

Summary

Predicted to enable death domain binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in positive regulation of hair follicle development. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in cytoplasm. Is expressed in adrenal gland; genitourinary system; liver; lung; and spleen. Orthologous to human TRADD (TNFRSF1A associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]

Tradd Products (1)

mRNA Protein Name
NM_001033161.2 NP_001028333.1 tumor necrosis factor receptor type 1-associated DEATH domain protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16702408 MGI
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
8565075 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22089168 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18641653 MGI
involved in positive regulation of hair follicle development IMP
IMP: Inferred from mutant phenotype
16702408 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16702408 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor type 1-associated DEATH domain protein

  • TNF receptor 1 associated signal transducer

  • TNFR1-associated DEATH domain protein

Tradd Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tradd Q3U0V2 Tlr4 Mus musculus Q9QUK6
Anti Bait CoIP
18719121
Intra
Tradd Q3U0V2 Ripk1 Mus musculus Q60855
Anti Bait CoIP
18719121
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134050 Apostatin-1 99.64% Unkown
HY-138779 ICCB-19 hydrochloride 99.25% Unkown
HY-114573 TNF-α-IN-19 Inhibitor / Unkown
HY-RS14966 TRADD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17209 Tradd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23661 Tradd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tradd NCBI NCBI:8717