country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

TRADD - TNFRSF1A associated via death domain Gene

Also Known as Hs.89862

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8717

About TRADD

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,154,185-67,159,909 (from NCBI)

This gene has 5 transcripts (splice variants) and 192 orthologues. Ubiquitous expression in stomach (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated Apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

TRADD Products (2)

mRNA	Protein	Name
NM_001323552.2	NP_001310481.1	tumor necrosis factor receptor type 1-associated DEATH domain protein
NM_003789.4	NP_003780.1	tumor necrosis factor receptor type 1-associated DEATH domain protein

TRADD Protein Structure

TRADD_N

Death

0
100
200
312 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor type 1-associated DEATH domain protein	TNFR1-associated death domain protein

TRADD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRADD	Q15628	KRT18	Homo sapiens	P05783	IF	11684708
Intra	TRADD	Q15628	KRT18	Homo sapiens	P05783	Y2H	11684708
Intra	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Y2H	8565075
Intra	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Y2H	7758105
Intra	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Anti Tag CoIP	23955153
Intra	TRADD	Q15628	TNFRSF1A	Homo sapiens	P19438	Anti Bait CoIP	7758105
Intra	TRADD	Q15628	TRAF2	Homo sapiens	Q12933	ViroTrap	30561431
Intra	TRADD	Q15628	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	23955153
Intra	TRADD	Q15628	FADD	Homo sapiens	Q13158	ViroTrap	30561431
Intra	TRADD	Q15628	FADD	Homo sapiens	Q13158	Anti Tag CoIP	23955153
Cross	TRADD	Q15628	nleB1	Escherichia coli O127:H6	B7UI21	Anti Tag CoIP	23955153
Cross	TRADD	Q15628	LMP1	Epstein-Barr virus	P03230	Anti Tag CoIP	18198944
Cross	TRADD	Q15628	LMP1	Epstein-Barr virus	P03230	Anti Bait CoIP	19379743

Cross: Cross-species interaction Intra: Intraspecies interaction

TRADD Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82531	TRADD Antibody (YA2276)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134050	Apostatin-1		99.64%	Unkown
HY-138779	ICCB-19 hydrochloride		99.25%	Unkown
HY-114573	TNF-α-IN-19	Inhibitor	/	Unkown
HY-RS14966	TRADD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17209	Tradd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23661	Tradd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRADD	MGD	MGI:109200
Macaca mulatta	TRADD	VGNC	VGNC:78640
Bos taurus	TRADD	VGNC	VGNC:36269
Rattus norvegicus	TRADD	RGD	RGD:621313
Canis familiaris	TRADD	VGNC	VGNC:47761
Others	TRADD	NCBI