FTI-249
FTI-249 is a farnesyl transferase inhibitor with an IC50 of 100-200 nM. FTI-249 acts as a linear competitive inhibitor targeting the peptide substrate of farnesyl transferase. FTI-249 is applicable for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 161721-65-9
- Formula: C15H23N3O3S2
- Molecular Weight:357.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
FTI-249 (100 nM; up to 50 min) acts as a classical linear competitive inhibitor of recombinant rat FTase, producing linear product formation kinetics when used at 100 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 161721-65-9
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Molecular Weight 357.49
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Formula C15H23N3O3S2
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SMILES
CSCC[C@@H](C(O)=O)NC(C1=CC=C(C=C1)NC[C@@H](N)CS)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Sebti SM, et al. Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacology & therapeutics. 1997;74(1):103-14. [Content Brief]
[2]. Roskoski R, et al. Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic. Biochemistry. 2001 Aug 07;40(31):9329-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTI-249 Related Classifications
HY-117524 Related Classifications
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