MLS-2064
MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma.
For research use only. We do not sell to patients.
- CAS No.: 906660-74-0
- Formula: C22H24BrCl2N5O2
- Molecular Weight:541.27
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MLS-2064 (compound 13j) (8 h) potently reduces the viability of various human tumor cell lines and embryonic kidney cell lines[1].
MLS-2064 (48 h) induces caspase-independent cell death in SH-SY5Y cells, as its cell viability inhibitory activity is not affected by the caspase inhibitor Q-VD-OPh[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HT-29, HCT116 colon cancer, MDA-MB-231 breast cancer, A549 lung cancer, PC3 prostate cancer, 5L, BP8, F1, Huh7 hepatoma, HEK293 embryonic kidney cells
-
Concentration:/
-
Incubation Time:48 h
-
Result:Exhibited the following IC50 values for cell viability inhibition after 48 h: HT-29 (6.3 μM), HCT116 (5.4 μM), MDA-MB-231 (5.3 μM), A549 (5.9 μM), PC3 (6.1 μM), 5L (5.2 μM), BP8 (5.6 μM), F1 (1.7 μM), Huh7 (5.3 μM), HEK293 (5.0 μM).
Chemical Information
-
CAS No. 906660-74-0
-
Molecular Weight 541.27
-
Formula C22H24BrCl2N5O2
-
SMILES
O=C(/C(C1=CC=C2)=C(NC3=CC=CC=C34)/C4=N/OCCN5CCNCC5)NC1=C2Br.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MLS-2064 Related Classifications
HY-111168 Related Classifications
Powered by Bioz