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Cat. No.: HY-156819R

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Zoldonrasib (Standard)

Name: Zoldonrasib (Standard)
Brand: MedChemExpress
SKU: HY-156819R
Availability: PreOrder

(Synonyms: RMC-9805 (Standard); KRAS G12D inhibitor 18 (Standard))

Zoldonrasib (Standard) is the analytical standard of Zoldonrasib (HY-156819). This product is intended for research and analytical applications. Zoldonrasib (RMC-9805) is a potent and orally active KRAS G12D inhibitor.Zoldonrasib induces apoptosis in KRAS G12D mutant cancer cells. Zoldonrasib has the potential for the research of KRAS G12D mutant cancer.

For research use only. We do not sell to patients.

CAS No.: 3034802-05-3
Formula: C₆₃H₈₈F₃N₁₁O₇
Molecular Weight:1168.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zoldonrasib (Standard) Chemical Structure

CAS No.: 3034802-05-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 3034802-05-3
Molecular Weight 1168.44
Formula C₆₃H₈₈F₃N₁₁O₇
SMILES

O=C([C@H]1NN(C([C@@H](NC([C@@H](N2C[C@]3(CN(C([C@@H]4N(C)[C@@H]4C5CC5)=O)CC3)CC2)C6CCCC6)=O)C[C@H]7CN8CCO7)=O)CCC1)OCC(C)(C)CC9=[C@@]([C@@]%10=C([C@@H](OC)C)N=CC(N%11CCN(C%12CC%12)CC%11)=C%10)N(CC(F)(F)F)C%13=C9C=C8C=C%13
Synonyms

RMC-9805 (Standard); KRAS G12D inhibitor 18 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. BLAKE JAMES F, et al. Preparation of peptide-linked macrocyclic dipeptides as Ras inhibitors.World Intellectual Property Organization, WO2023060253 A1 2023-04-13

[2]. Knox, J et al.RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models. Cancer Res 1 April 2023; 83 (7_Supplement): 3475

[3]. John E. Knox, et al. Discovery of RMC-9805, an Oral, RAS(ON) G12D-Selective Covalent Tri-Complex Inhibitor.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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