Azatadine
Azatadine is an orally active histamine H1 receptor inhibitor, cetylcholine receptor inhibitor, and serotonin receptor inhibitor. Azatadine induces sedation and exhibits topical anesthetic properties. Azatadine can be used for the research of allergic rhinitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3964-81-6
- 分子式: C20H22N2
- 分子量:290.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Azatadine (3.4 nM-13 nM; 3 minutes) competitively inhibits Histamine (HY-B1204)-induced contractions in isolated guinea-pig ileum segments with an ED50 of 6.5 nM[1].
Azatadine (6.8 nM-27 nM; 3 minutes) competitively inhibits acetylcholine-induced contractions in isolated guinea-pig ileum segments with an ED50 of 10 nM[1].
Azatadine (6.8 nM-27 nM; 3 minutes) inhibits Serotonin (HY-B1473A)-induced contractions in isolated unprimed virgin rat uterus segments with an ED50 of 14 nM[1].
Azatadine (50 μM-1 mM) dose-dependently inhibits anti-IgE-induced Histamine and Leukotriene C4 (HY-113446) release from human lung mast cells, with significantly greater inhibition of Leukotriene C4 release (85% at 1 mM) compared to histamine release (45% at 1 mM)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Azatadine (p.o.; single dose) potently delays the onset of Histamine-induced dyspnea in guinea-pigs, with an oral ED200 of 0.01 mg/kg[1].
Azatadine (p.o.; single dose) delays the onset of acetylcholine-induced dyspnea in guinea-pigs, with an oral ED200 of 0.739 mg/kg[1].
Azatadine (p.o.; single dose) delays the onset of Serotonin-induced dyspnea in guinea-pigs with an oral ED200 of 0.860 mg/kg[1].
Azatadine (p.o.; single dose) exhibits potent antianaphylactic activity in sensitized guinea-pigs, with an oral PD50 of 0.024 mg/kg for protection against anaphylactic shock[1].
Azatadine (p.o.; single dose) potently protects pertussis-sensitized mice against Histamine-induced lethality, with an oral PD50 of 0.022 mg/kg[1].
Azatadine (p.o.; single dose) exhibits potent antianaphylactic activity in sensitized mice, with an oral PD50 of 0.019 mg/kg for protection against anaphylactic shock[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3964-81-6
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分子量 290.40
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分子式 C20H22N2
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SMILES
CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C4\2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tozzi S, et al. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4(4):264-70. [Content Brief]
[2]. Katelaris C, et al. Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990;8(2):103-107. [Content Brief]
[3]. Togias AG, et al. Demonstration of inhibition of mediator release from human mast cells by azatadine base. In vivo and in vitro evaluation. JAMA. 1986 Jan 10;255(2):225-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Azatadine 関連分類
HY-B0170 関連分類
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