Biliverdin hydrochloride
Based on 1 publication(s) in Google Scholar
Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.3%
- CAS 番号: 856699-18-8
- 分子式: C33H35ClN4O6
- 分子量:619.11
-
保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Biliverdin hydrochloride
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
|
Human Endogenous Metabolite |
体外実験
Biliverdin hydrochloride is considered a waste product of heme degradation. When red blood cells lyse, either due to hemolytic diseases or by natural apoptosis, heme get released. The heme is metabolized by heme oxygenase using three molecules of oxygen and seven electrons and producing Biliverdin IX-alpha, carbon monoxide, and ferrous iron. The Biliverdin IX-alpha undergoes metabolism to bilirubin IX-alpha via NADPH-dependent Biliverdin reductase[1].
The buildup of Biliverdin hydrochloride has been shown to upregulate the activity of Biliverdin hydrochloride reductase, an enzyme that is a regulator of the innate immune system[1].
Biliverdin hydrochloride downregulates the proliferation of vascular smooth muscle cells and demonstrate an antioxidant effect in the damaged blood vessels. This decreases the formation of the tunica intima of blood vessels and blocks neovascularization and angiogenesis[1].
Biliverdin hydrochloride decreases inflammation by downregulating pro-inflammatory cytokines such as TLR-4 and by stimulating the production of anti-inflammatory cytokines such as IL-10[1].
Biliverdin hydrochloride is a scavenger of hydroxyl peroxide groups showing the antioxidant effects of Biliverdin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 856699-18-8
-
性状 Solid
-
分子量 619.11
-
分子式 C33H35ClN4O6
-
Color Green to dark green
-
SMILES
OC(CCC1=C(C)C(/C=C(N2)/C(C=C)=C(C)C2=O)=N/C1=C\C3=C(C(C)=C(/C=C(N4)/C(C)=C(C=C)C4=O)N3)CCC(O)=O)=O.Cl
-
Structure Classification
-
Initial Source
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Virol
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]2026 Feb 17;100(2):e0165625. PMID: 41489372
溶剤 & 溶解度
体外:
DMSO : 20 mg/mL (32.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (282 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6152 mL | 8.0761 mL | 16.1522 mL | 40.3805 mL |
| 5 mM | 0.3230 mL | 1.6152 mL | 3.2304 mL | 8.0761 mL | |
| 10 mM | 0.1615 mL | 0.8076 mL | 1.6152 mL | 4.0381 mL | |
| 15 mM | 0.1077 mL | 0.5384 mL | 1.0768 mL | 2.6920 mL | |
| 20 mM | 0.0808 mL | 0.4038 mL | 0.8076 mL | 2.0190 mL | |
| 25 mM | 0.0646 mL | 0.3230 mL | 0.6461 mL | 1.6152 mL | |
| 30 mM | 0.0538 mL | 0.2692 mL | 0.5384 mL | 1.3460 mL |
Biliverdin hydrochloride 関連分類
HY-135005 関連分類
Powered by Bioz