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製品番号: HY-177269

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CHNQD-01269

CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC₅₀ values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2648988-92-3
分子式: C₂₇H₃₅NO₅
分子量:453.57

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CHNQD-01269 構造式

CAS 番号: 2648988-92-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Bel-7402	IC₅₀	0.84 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human Bel-7402 cells measured after 72 hrs by MTT assay Antiproliferative activity against human Bel-7402 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
HeLa	IC₅₀	0.86 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells measured after 72 hrs by MTT assay	[PMID: 35849940]
HepG2	IC₅₀	0.29 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
L02	IC₅₀	2.81 μM Compound: 33; CHNQD-01269	Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay	[PMID: 35849940]
PANC-1	IC₅₀	0.64 μM Compound: 33; CHNQD-01269	Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay Antiproliferative activity against human PANC-1 cells measured after 72 hrs by MTT assay	[PMID: 35849940]

化学情報

CAS 番号 2648988-92-3
分子量 453.57
分子式 C₂₇H₃₅NO₅
SMILES

CN(C)C(C=C1)=CC=C1/C=C/C(O[C@H]2[C@@]3([H])[C@@](/C=C/CCC[C@@H](OC(/C=C/2)=O)C)([H])C[C@@H](C3)O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jiang YY, et al. New brefeldin A-cinnamic acid ester derivatives as potential antitumor agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Oct 5;240:114598. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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