DBCO-PEG1000-FA
DBCO-PEG1000-FA (DBCO-PEG1000-Folate) is a multifunctional bioconjugation reagent, which is a copolymer of DBCO and Folic acid (FA) (HY-16637) and can target folate receptors (FR). Folate receptors are highly overexpressed on the surface of many cancer cells (such as lung cancer, nasopharyngeal cancer, ovarian cancer, etc.), but exhibit extremely low expression levels in normal tissues. DBCO-PEG-FA can be used for click chemistry conjugation via its DBCO terminal, and thus applies to various bioconjugation and drug delivery applications.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子量:1000 (Average)
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
DBCO-PEG-FA acts as a targeting guide molecule to direct europium-labeled MS2 virus-like particles to human nasopharyngeal carcinoma cells with high folate receptor expression, thereby enabling ultra-high sensitivity cancer cell counting detection[1].
DBCO-PEG-FA is used to modify a CRISPR-Cas9 gene biological nanoparticle to enhance its targeting ability and anti-tumor effect[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1000 (Average)
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SMILES
O=C(CCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)NCCOCCNC(CCC(C(O)=O)NC(C4=CC=C(C=C4)NCC5=NC6=C(C(O)=NC(N)=N6)N=C5)=O)=O.[n]
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別名
DBCO-PEG1000-Folate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Yuan R, et al. Viruslike Element-Tagged Nanoparticle Inductively Coupled Plasma Mass Spectrometry Signal Multiplier: Membrane Biomarker Mediated Cell Counting. Anal Chem. 2019;91(8):4948-4952. [Content Brief]
[2]. Ren Y, et al. A Recombinant Targeted Bionanoparticle In Vitro Expressing a Gene-Editing Protein for Epidermal Growth Factor Receptor Mutant Lung Cancer. ACS Nano. 2026;20(6):4920-4941. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DBCO-PEG1000-FA 関連分類
HY-W1123936B 関連分類
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