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製品番号: HY-187649

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FLAD1-IN-1

FLAD1-IN-1 is a FLAD1 inhibitor. FLAD1-IN-1 impairs the activity of mitochondrial complex II by disrupting the intracellular FAD pool, thereby inducing cellular mitochondrial dysfunction and reducing hypoxic tolerance. FLAD1-IN-1 exhibits anticancer activity against hypoxic tumors. FLAD1-IN-1 can be used in the research of lung cancer.

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CAS 番号: 2696100-70-4
分子式: C₂₃H₂₂N₂O₅
分子量:406.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

FLAD1-IN-1 構造式

CAS 番号: 2696100-70-4

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

FLAD1-IN-1 (Compound C4-31) directly inhibits wild-type recombinant FLAD1 protein activity, with its binding dependent on the FLAD1^G487 residue of FLAD1^[1].
FLAD1-IN-1 (~1-~100 μM; 48 h) selectively inhibits the viability of hypoxic PC9 lung cancer cells with greater potency than in normoxic PC9 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC9 human lung cancer cells
Concentration:

~1-~100 μM
Incubation Time:

48 h
Result:

Selectively inhibited the viability of hypoxic PC9 cells compared to normoxic PC9 cells.
Exhibited a lower IC₅₀ under hypoxic conditions.

化学情報

CAS 番号 2696100-70-4
分子量 406.43
分子式 C₂₃H₂₂N₂O₅
SMILES

CCOC(COC1=C(C=C(C=C1)/C=N\NC(C2=CC3=C(C=C2)C=CC=C3)=O)OC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhao X, et al. Deep learning reveals FLAD1-mediated mitochondrial metabolic reprogramming in hypoxic tumors. Cell reports. 2026 Jul 28;45(7):117711.

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モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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