MAPT - microtubule associated protein tau Gene

Also Known as TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4137

About MAPT

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,894,554-46,028,334 (from NCBI)

This gene has 30 transcripts (splice variants), 1 gene allele, 225 orthologues, 1 paralogue and is associated with 13 phenotypes. Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues.

Summary

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

MAPT Products (41)

mRNA	Protein	Name
NM_016834.5	NP_058518.1	microtubule-associated protein tau isoform 3
XM_047436074.1	XP_047292030.1	microtubule-associated protein tau isoform X4
XM_047436076.1	XP_047292032.1	microtubule-associated protein tau isoform X7
XM_047436077.1	XP_047292033.1	microtubule-associated protein tau isoform X9
XM_005257367.5	XP_005257424.1	microtubule-associated protein tau isoform X5
XM_005257370.5	XP_005257427.1	microtubule-associated protein tau isoform X12
XM_047436078.1	XP_047292034.1	microtubule-associated protein tau isoform X10
NM_001377268.1	NP_001364197.1	microtubule-associated protein tau isoform 4
XM_005257362.5	XP_005257419.1	microtubule-associated protein tau isoform X1
XM_005257368.5	XP_005257425.1	microtubule-associated protein tau isoform X8
NM_001123066.4	NP_001116538.2	microtubule-associated protein tau isoform 6
NM_005910.6	NP_005901.2	microtubule-associated protein tau isoform 2
NM_001123067.4	NP_001116539.1	microtubule-associated protein tau isoform 5
XM_047436079.1	XP_047292035.1	microtubule-associated protein tau isoform X13
NM_001377265.1	NP_001364194.1	microtubule-associated protein tau isoform 9
XM_047436075.1	XP_047292031.1	microtubule-associated protein tau isoform X6
NM_016835.5	NP_058519.3	microtubule-associated protein tau isoform 1
NM_016841.5	NP_058525.1	microtubule-associated protein tau isoform 4
XM_005257366.4	XP_005257423.1	microtubule-associated protein tau isoform X3
NR_165166.1
XM_047436081.1	XP_047292037.1	microtubule-associated protein tau isoform X16
XM_005257365.5	XP_005257422.1	microtubule-associated protein tau isoform X2
XM_005257371.5	XP_005257428.1	microtubule-associated protein tau isoform X14
NM_001377266.1	NP_001364195.1	microtubule-associated protein tau isoform 10
NM_001377267.1	NP_001364196.1	microtubule-associated protein tau isoform 11
XM_047436080.1	XP_047292036.1	microtubule-associated protein tau isoform X15
NM_001203252.2	NP_001190181.1	microtubule-associated protein tau isoform 8
NM_001203251.2	NP_001190180.1	microtubule-associated protein tau isoform 7
XM_005257369.5	XP_005257426.1	microtubule-associated protein tau isoform X11
NM_001123066.4	NP_001116538.2	microtubule-associated protein tau isoform 6
NM_001123067.4	NP_001116539.1	microtubule-associated protein tau isoform 5
NM_001203251.2	NP_001190180.1	microtubule-associated protein tau isoform 7
NM_001203252.2	NP_001190181.1	microtubule-associated protein tau isoform 8
NM_001377265.1	NP_001364194.1	microtubule-associated protein tau isoform 9
NM_001377266.1	NP_001364195.1	microtubule-associated protein tau isoform 10
NM_001377267.1	NP_001364196.1	microtubule-associated protein tau isoform 11
NM_001377268.1	NP_001364197.1	microtubule-associated protein tau isoform 4
NM_005910.6	NP_005901.2	microtubule-associated protein tau isoform 2
NM_016834.5	NP_058518.1	microtubule-associated protein tau isoform 3
NM_016835.5	NP_058519.3	microtubule-associated protein tau isoform 1
NM_016841.5	NP_058525.1	microtubule-associated protein tau isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	17517623	GOA
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	9763511	GOA
enables apolipoprotein binding	IPI IPI: Inferred from physical interaction	7566652	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	9736630	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	15654759	GOA
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	7929085	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16446437	GOA
enables lipoprotein particle binding	IPI IPI: Inferred from physical interaction	7972031	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	1918161	GOA
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	10747907	GOA
enables microtubule lateral binding	IMP IMP: Inferred from mutant phenotype	15147841	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	3111527	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16923168	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	25051234	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21131359	GOA
involved in amyloid fibril formation	EXP EXP: Inferred from Experiment	7929085	GOA
involved in amyloid fibril formation	IDA IDA: Inferred from direct assay	7929085	GOA
involved in amyloid fibril formation	IEP IEP: Inferred from expression pattern	14769047	GOA
involved in amyloid fibril formation	IMP IMP: Inferred from mutant phenotype	7929085	GOA
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	21854751	GOA
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	26704708	GOA
involved in memory	IMP IMP: Inferred from mutant phenotype	20655099	GOA
involved in microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	1057175	GOA
involved in microtubule polymerization	IDA IDA: Inferred from direct assay	26996940	GOA
involved in negative regulation of establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	22920254	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23164821	GOA
involved in negative regulation of kinase activity	IMP IMP: Inferred from mutant phenotype	20655099	GOA
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	22920254	GOA
involved in negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	22920254	GOA
involved in negative regulation of tubulin deacetylation	IGI IGI: Inferred from genetic interaction	19457097	GOA
involved in positive regulation of axon extension	IDA IDA: Inferred from direct assay	1389180	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	1421571	GOA
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	27356871	GOA
involved in positive regulation of protein localization to synapse	IMP IMP: Inferred from mutant phenotype	20655099	GOA
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	22920254	GOA
involved in protein homooligomerization	IPI IPI: Inferred from physical interaction	26704708	GOA
involved in protein polymerization	IMP IMP: Inferred from mutant phenotype	27044754	GOA
acts upstream of or within regulation of autophagy	IGI IGI: Inferred from genetic interaction	19074461	GOA
involved in regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	18272392	GOA
involved in regulation of cellular response to heat	IMP IMP: Inferred from mutant phenotype	21131359	GOA
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15147841	GOA
involved in regulation of microtubule polymerization or depolymerization	IMP IMP: Inferred from mutant phenotype	27356871	GOA
involved in supramolecular fiber organization	IDA IDA: Inferred from direct assay	15654759	GOA
involved in supramolecular fiber organization	IMP IMP: Inferred from mutant phenotype	14769047	GOA
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	26704708	GOA
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	17270732	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in axolemma	IDA IDA: Inferred from direct assay	10747907	GOA
located in axon	IDA IDA: Inferred from direct assay	8642405	GOA
located in cell body	IDA IDA: Inferred from direct assay	25620700	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23666762	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	26014385	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10747907	GOA
located in dendrite	IDA IDA: Inferred from direct assay	23666762	GOA
located in growth cone	IDA IDA: Inferred from direct assay	8642405	GOA
colocalizes with membrane	IMP IMP: Inferred from mutant phenotype	20655099	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	15147841	GOA
located in neurofibrillary tangle	IDA IDA: Inferred from direct assay	2484340	GOA
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	20655099	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	19157893	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8522593	GOA
located in somatodendritic compartment	IMP IMP: Inferred from mutant phenotype	20655099	GOA
part of tubulin complex	IDA IDA: Inferred from direct assay	8642405	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPT Protein Structure

Tubulin-binding

0
200
400
600
758 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein tau	G protein beta1/gamma2 subunit-interacting factor 1 PHF-tau neurofibrillary tangle protein paired helical filament-tau protein phosphatase 1, regulatory subunit 103

MAPT Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MAPT	P10636	STUB1	Homo sapiens	Q9UNE7-1	Anti Tag CoIP	18292230
Intra	MAPT	P10636	AKT1	Homo sapiens	P31749	Anti Tag CoIP	18292230
Intra	MAPT	P10636	YWHAZ	Homo sapiens	P63104	Biochemical	19647741
Intra	MAPT	P10636	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	17317006
Intra	MAPT	P10636	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	Comigration in SDS	16446437
Intra	MAPT	P10636	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR	16446437
Intra	MAPT	P10636	APP	Homo sapiens	P05067	Confocal	16446437
Intra	MAPT	P10636	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	ELISA	16446437
Intra	MAPT	P10636	APP	Homo sapiens	P05067	ELISA	16446437
Intra	MAPT	P10636	RPL28	Homo sapiens	P46779	Anti Bait CoIP	26402096
Intra	MAPT	P10636	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	31640277
Intra	MAPT	P10636	GSK3B	Homo sapiens	P49841	Protein Kinase Assay	17078951
Intra	MAPT	P10636	CAPN10	Homo sapiens	Q9HC96	Y2H Array	32814053
Intra	MAPT	P10636	CAPN10	Homo sapiens	Q9HC96	Y2H Pooling	32814053
Intra	MAPT	P10636	CAPN10	Homo sapiens	Q9HC96	Validated Y2H	32814053
Intra	MAPT	P10636	FYN	Homo sapiens	P06241	Pull Down	21692989
Intra	MAPT	P10636	DENR	Homo sapiens	O43583	Anti Bait CoIP	34757590
Intra	MAPT	P10636	DENR	Homo sapiens	O43583	Anti Tag CoIP	33961781
Intra	MAPT	P10636	MAPRE3	Homo sapiens	Q9UPY8	Filter Binding	30668577
Intra	MAPT	P10636	P02649-PRO_0000001987	Homo sapiens	P02649-PRO_0000001987	Electrophoresis	7566652
Intra	MAPT	P10636	PRNP	Homo sapiens	P04156	Anti Bait CoIP	24028865

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPT Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70589	Tau-F/2N4R Protein, Human	P10636-8 (M1-L441)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71102	Tau-D/0N4R Protein, Human (133a.a, His)	P10636-6 (Q249-Q381)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73618	Fetal-tau/0N3R Protein, Human (His, solution)	P10636-2/NP_058525.1 (A2-L352)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P700421	Tau-F/2N4R Protein, Human (HEK293, His)	P10636-8 (M1-L441)	≥ 95%, as determined by reducing SDS-PAGE.

MAPT 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80480	Phospho-Tau (Ser396) Antibody (YA140)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue	Human, Mouse, Rat, Monkey, Pig
HY-P80859	Phospho-Tau (Ser198) Antibody (YA143)	WB, IP	Human
HY-P80859A	Phospho-Tau (Ser198) Antibody (YA143)(PBS only)	WB, IP	Human
HY-P80860	Phospho-Tau (Ser404) Antibody (YA142)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80860A	Phospho-Tau (Ser404) Antibody (YA142)(PBS only)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80861	Phospho-Tau (Thr181) Antibody (YA141)	WB, IP	Human
HY-P80861A	Phospho-Tau (Thr181) Antibody (YA141)(PBS only)	WB, IP	Human
HY-P80909	Tau Antibody (YA041)	WB	Human, Mouse, Rat
HY-P80909A	Tau Antibody (YA041)(PBS only)	WB	Human, Mouse, Rat
HY-P810305	Tau Antibody (YA9640)	WB, IHC-P, IP, IF-Tissue	Mouse, Rat, Pig
HY-P810630	Phospho-Tau (Ser202) Antibody (YA9892)	WB	Human, Mouse, Rat
HY-P83700	Phospho-Tau (Ser202/Thr205) Antibody (YA3436)	WB, IP	Human
HY-P83700A	Phospho-Tau (Ser202/Thr205) Antibody (YA3436)(PBS only)	WB, IP	Human
HY-P83778	Phospho-Tau (T217) Antibody (YA3476)	WB, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
HY-P83779	Phospho-Tau (T231) Antibody (YA3477)	WB, IHC-P, IHC-F, IP, IF-Tissue	Human, Mouse, Rat
HY-P85769	Tau Antibody (YA5461)	WB, IHC-P, ICC/IF	Human, Rat, Mouse
HY-P86125	Tau Antibody (YA5817)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P87032	Phospho-Tau (S198) Antibody (YA6725)	WB	Human, Mouse, Rat
HY-P87033	Phospho-Tau (S199) Antibody (YA6726)	WB	Human, Mouse, Rat
HY-P87034	Phospho-Tau (S214) Antibody (YA6727)	WB	Human
HY-P87035	Phospho-Tau (S324) Antibody (YA6728)	WB	Human
HY-P87036	Phospho-Tau (S356) Antibody (YA6729)	WB	Human
HY-P87037	Phospho-Tau (S404) Antibody (YA6730)	WB, IHC-P	Human, Mouse, Rat
HY-P87038	Phospho-Tau (T181) Antibody (YA6731)	WB, IHC-P	Human, Mouse
HY-P87039	Phospho-Tau (T231) Antibody (YA6732)	WB, IHC-P	Human, Mouse, Rat

関連疾患

Diseases	Alias
Gerstmann Syndrome	Aphasia-Angular Gyrus Syndrome Developmental Gerstmann Syndrome Gs Gerstmann Badal Syndrome Gerstmann Tetrad Gerstmann'S Syndrome Developmental Gerstmann'S Syndrome
Aphasia
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7	Ftd3 Frontotemporal Dementia, Chromosome 3-Linked Amyotrophic Lateral Sclerosis, Chmp2b-Related Chromosome 3-Linked Frontotemporal Dementia FTDALS7 Chmp2b-Related Frontotemporal Dementia Amyotrophic Lateral Sclerosis 17, Formerly Als17, Formerly Amyotrophic Lateral Sclerosis Type 17 Dtm1 Ftd-3 Ftd-Chmp2b Als17 Amyotrophic Lateral Sclerosis 17 Sclerosis, Lateral, Amyotrophic, Type 17 Dementia, Frontotemporal, Chromosome 3-Linked
Dysgraphia	Agraphia
Parkinson-Dementia Syndrome	Progressive Supranuclear Palsy-Parkinsonism Syndrome Supranuclear Palsy, Progressive Atypical Progressive Supranuclear Palsy Atypical Atypical Psp Psp-P Psp-Parkinsonism Atypical Progressive Supranuclear Palsy Syndrome Atypical Psp Syndrome PARDE Steele-Richardson-Olszewski Syndrome Atypical Supranuclear Palsy Progressive 1 Atypical Supranuclear Palsy, Progressive, 1, Atypical
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Corticobasal Degeneration
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Vascular Dementia	Dementia, Vascular Multi Infarct Dementia Multifocal Dementia Dementia Vascular Vascular Dementia, Susceptibility To Dementia, Multi-Infarct Multi-Infarct Dementia
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome	Psp-Pagf Psp-Pure Akinesia With Gait Freezing
Chromosomal Duplication Syndrome
Parkinson Disease 3, Autosomal Dominant	Parkinson Disease 3 PARK3 Parkinson Disease 3, Autosomal Dominant Lewy Body Parkinson'S Disease 3 Autosomal Dominant Lewy Body Parkinson Disease 3 Autosomal Dominant Parkinson Disease 3 Parkinson Disease Type 3 Autosomal Dominant Parkinson Disease Parkinson Disease, Autosomal Dominant Parkinson Disease, Familial, Type 1
Prosopagnosia
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Guam Disease Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam Als-Pdc Lytico-Bodig Disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome Parkinsonism-Dementia-Als Complex Pdals Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam Parkinson-Dementia Complex Of Guam G-Pdc Guam Parkinsonism-Dementia Complex ALS-PDC1 Als/Pdc Of Guam Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1 Amyotrophic Lateral Sclerosis, Guam Form Parkinsonian Disorders
Writing Disorder
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Paralytic Lagophthalmos
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Nominal Aphasia	Anomia Anomic Aphasia
Hereditary Late-Onset Parkinson Disease	Autosomal Dominant Late-Onset Parkinson Disease Lopd Hereditary Late Onset Parkinson Disease
Myxoid Chondrosarcoma
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Apperceptive Agnosia
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Postencephalitic Parkinson Disease	Postencephalitic Parkinsonism Parkinson Disease, Postencephalitic
Capgras Syndrome	Capgras Delusion Theory
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Subjective Cognitive Decline
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Cerebral Amyloid Angiopathy, Familial Hereditary Cystatin C Amyloid Angiopathy Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Vascular Parkinsonism
Arteriolosclerosis
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Specific Developmental Disorder
Associative Agnosia
Alzheimer Disease 10	Ad10 Alzheimer Disease-10 Alzheimer'S Disease 10 Alzheimer Disease, Familial, 10 Alzheimer Disease Familial 10 Alzheimer'S Disease 10, Early Onset
Coenzyme Q10 Deficiency, Primary, 1	COQ10D1 Ubiquinone Deficiency 1 Coenzyme Q Deficiency 1 Coq Deficiency 1 Coq10 Deficiency, Primary, 1 Primary Coenzyme Q10 Deficiency 1 Primary Coq10 Deficiency 1 Coenzyme Q10 Deficiency, Primary, Type 1
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Myositis, Inclusion Body Inflammatory Myopathy Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Ideomotor Apraxia	Apraxia, Ideomotor Classic Apraxia Ideomotor Dyspraxia Limb-Kinetic Apraxia Transcortical Apraxia
Alzheimer Disease 9	AD9 Alzheimer'S Disease 9 Alzheimer Disease 9, Susceptibility To Alzheimer Disease 9, Late-Onset Alzheimer'S Disease 9, Late Onset {Alzheimer Disease 9, Susceptibility To}
Mutism
Gerstmann-Straussler Disease	Gerstmann-Straussler-Scheinker Disease Gerstmann-Straussler-Scheinker Syndrome Prion Dementia Cerebral Amyloid Angiopathy, Prnp-Related GSD Gss Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns Amyloidosis, Cerebral, With Spongiform Encephalopathy Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type Amyloidosis Cerebral With Spongiform Encephalopathy Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System Encephalopathy Subacute Spongiform Gerstmann-Straussler Type Gssd Gerstmann Straussler Scheinker Syndrome Cerebral Amyloidosis With Spongiform Encephalopathy Subacute Spongiform Encephalopathy Gerstmann-Straussler Type Gluthathione Synthetase Deficiency Gerstmann Straussler Syndrome
Cortical Deafness
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Speech Disorder	Speech Disorders
Echolalia
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Agraphia
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Familial Spastic Paraparesis Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2	Ibmpfd2 Msp2 Multisystem Proteinopathy 2
Pseudobulbar Palsy	Pseudobulbar Paralysis
Rem Sleep Behavior Disorder	Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behavior Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Akinetic Mutism	Coma Vigilans
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Progressive Non-Fluent Aphasia	Non-Fluent Variant Ppa Non-Fluent Primary Progressive Aphasia Agramatic Variant Of Ppa Agramatic Variant Of Primary Progressive Aphasia Progressive Nonfluent Aphasia Primary Progressive Non Fluent Aphasia Primary Progressive Nonfluent Aphasia
Lumbosacral Plexus Lesion	Lumbosacral Plexus Lesions
Tremor	Medicament-Induced Tremor Medication-Induced Postural Tremor
Perry Syndrome	Parkinsonism With Alveolar Hypoventilation And Mental Depression PERRYS
Diabetes Mellitus	Diabetes
Mild Cognitive Impairment
Anosognosia
Fatal Familial Insomnia	Insomnia, Fatal Familial FFI Familial Fatal Insomnia Insomnia Familial Fatal Insomnia Fatal Familial Insomnia, Fatal, Familial Ffi - [Fatal Familial Insomnia]
Binswanger'S Disease	Multi-Infarct Dementia Dementia Multi-Infarct Binswanger Disease
Scrapie
Visual Agnosia	Primary Visual Agnosia
Progressive Supranuclear Palsy-Corticobasal Syndrome	Psp-Cbs Psp-Corticobasal Syndrome
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Niemann-Pick Disease, Type C1	Niemann-Pick Disease, Type C NPC1 Niemann-Pick Disease, Type D Niemann-Pick Disease Type C1 Niemann-Pick Disease With Cholesterol Esterification Block Niemann-Pick Disease, Subacute Juvenile Form Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia Npc Niemann-Pick Disease, Chronic Neuronopathic Form Niemann-Pick Disease Without Sphingomyelinase Deficiency Niemann-Pick Disease Type C Niemann-Pick Disease Type D Niemann-Pick C1 Disease Niemann-Pick Disease C1 Niemann-Pick Disease Chronic Neuronopathic Form Niemann-Pick Disease Nova Scotian Type Niemann-Pick Disease Subacute Juvenile Form Niemann-Pick Disease Type Ii Niemann-Picks Disease Type C
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Finger Agnosia
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Intellectual Developmental Disorder, Autosomal Dominant 55, With Seizures	MRD55 Mental Retardation, Autosomal Dominant 55, With Seizures Autosomal Dominant Mental Retardation 55 Autosomal Dominant Intellectual Developmental Disorder 55 Autosomal Dominant Intellectual Developmental Disorder-55 With Seizures Mental Retardation, Autosomal Dominant, Type 55, With Seizures
Alzheimer Disease 11	Ad11 Alzheimer'S Disease 11 Alzheimer Disease, Familial, 11 Alzheimer Disease-11 Alzheimer'S Disease 11, Late Onset
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Ibmpfd Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia Pagetoid Amyotrophic Lateral Sclerosis Pagetoid Neuroskeletal Syndrome Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia Multisystem Proteinopathy Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement Lower Motor Neuron Degeneration With Paget-Like Bone Disease Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Movement Disease	Movement Disorders Movement Disorder
Apraxia	Apraxias Dyspraxia
Choreatic Disease	Chorea Hereditary Chorea
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Kuru	Kuru, Susceptibility To Kuru Encephalopathy Kuru Encephalitis Kuru Disease
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Disease Of Mental Health	Mental Health Mental Disorders
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Koolen-De Vries Syndrome	KDVS 17q21.31 Microdeletion Syndrome Microdeletion 17q21.31 Syndrome Chromosome 17q21.31 Deletion Syndrome Koolen De Vries Syndrome Kansl1-Related Intellectual Disability Syndrome Chromosome 17q21.31 Microdeletion Syndrome Monosomy 17q21.31 17q21.31 Deletion Syndrome Koolen Syndrome Del(17)(Q21.31)
Demyelinating Disease	Demyelinating Diseases Demyelinating Disorder
Progressive Supranuclear Palsy-Progressive Non-Fluent Aphasia Syndrome	Psp-Aos Psp-Pnfa Progressive Supranuclear Palsy-Apraxia Of Speech Syndrome
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	FTDALS1 Frontotemporal Dementia And/Or Motor Neuron Disease Ftdmnd Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia Alsftd Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1 Frontotemporal Dementia With Motor Neuron Disease Ftdals Ftd-Als Ftd-Mnd Frontotemporal Dementia With Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1 Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1 Frontotemporal Lobar Degeneration Grn-Related Frontotemporal Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Miyoshi Muscular Dystrophy	Distal Myopathy Distal Muscular Dystrophy Miyoshi Myopathy Distal Myopathies Dystrophy, Muscular, Miyoshi Myopathy, Distal Distal Muscular Dystrophies
Neuritis	Peripheral Neuritis
Simultanagnosia
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Communicating Hydrocephalus	Acquired Communicating Hydrocephalus
Classic Progressive Supranuclear Palsy Syndrome	Classic Psp Syndrome Richardson Syndrome Steele-Richardson-Olszewski Disease Progressive Supranuclear Palsy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Temporal Lobe Neoplasm	Neoplasm Of Temporal Lobe Malignant Neoplasm Of Temporal Lobe Tumor Of Temporal Lobe
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related	Primary Progressive Aphasia Grn-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions Frontotemporal Dementia, Ubiquitin-Positive Aphasia, Primary Progressive Ppa Ftld-Tdp, Grn-Related Frontotemporal Dementia With Tdp43 Inclusions, Grn-Related Ftldu Ftdu Dementia, Hereditary Dysphasic Disinhibition Hddd Primary Progressive Aphasia Syndrome Mesulam Syndrome Ubiquitin-Positive Frontotemporal Dementia UP-FTD Tau-Negative Frontotemporal Dementia Linked To Chromosome 17 Aphasia Primary Progressive Frontotemporal Lobar Degeneration With Ubiquitin-Positive Inclusions, Susceptibility To Aphasia, Primary Progressive, Susceptibility To Frontotemporal Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Phase
HY-132582C	Diranersen sodium	Inhibitor	91.82%	Phase 2

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P991373	APNmAb005	Inhibitor	97.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-132582	Diranersen	Inhibitor	93.23%	Unkown
HY-P4808A	PHF6 TFA	Activator	99.45%	Unkown
HY-P4808	PHF6	Activator	99.17%	Unkown
HY-147149	BPN-15477	Modulator	99.92%	Unkown
HY-RS08140	MAPT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08141	Mapt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174215	TAU-IN-3	Inhibitor	/	Unkown
HY-RS08142	Mapt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	MAPT	VGNC	VGNC:43012
Felis catus	MAPT	VGNC	VGNC:68182
Rattus norvegicus	MAPT	RGD	RGD:69329
Mus musculus	MAPT	MGD	MGI:97180
Macaca mulatta	MAPT	VGNC	VGNC:99169
Bos taurus	MAPT	VGNC	VGNC:57143
Others	MAPT	NCBI