2. Neuronal Signaling
  3. Tau Protein
  4. Diranersen

Diranersen  (Synonyms: IONIS-MAPTRx; BIIB080; ISIS 814907)

Cat. No.: HY-132582 Purity: 93.23%
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Handling Instructions Technical Support

Diranersen (IONIS-MAPTRx) is an antisense oligonucleotide that targets the human MAPT gene to inhibit the production of tau protein. Diranersen can be used in research related to Alzheimer's disease and tauopathies.

For research use only. We do not sell to patients.

RNA, ([2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]G-sp-[2′-O-(2-methoxyethyl)]m5U-sp-[2′-O-(2-methoxyethyl)]m5U-sp-dT-sp-dT-sp-m5dC-sp-dT-sp-dT-sp-dA-sp-m5dC-sp-m5dC-sp-[2′-O-(2-methoxyethyl)]A-sp-[2′-O-(2-methoxyethyl)]m5C-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5C-sp-[2′-O-(2-methoxyethyl)]m5U)

Diranersen Chemical Structure

CAS No. : 2304711-06-4

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Based on 1 publication(s) in Google Scholar

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Description

Diranersen (IONIS-MAPTRx) is an antisense oligonucleotide that targets the human MAPT gene to inhibit the production of tau protein. Diranersen can be used in research related to Alzheimer's disease and tauopathies[1].

In Vivo

Diranersen (intrathecal administration; single dose) significantly reduces MAPT mRNA levels in the brains of non-human primates with favorable safety profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Non-human primates[1]
Dosage: /
Administration: Intrathecal administration, single dose
Result: Induced a mean MAPT mRNA reduction of 77% in the frontal cortex and 74% in the hippocampus, and no adverse effects were observed in non-human primates.
Clinical Trial
Molecular Weight

6430.39

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Diranersen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (15.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1555 mL 0.7776 mL 1.5551 mL
5 mM 0.0311 mL 0.1555 mL 0.3110 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 93.23%

SDS (251 KB)

COA (246 KB) LCMS (349 KB)

Handling Instructions (2242 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.1555 mL 0.7776 mL 1.5551 mL 3.8878 mL
5 mM 0.0311 mL 0.1555 mL 0.3110 mL 0.7776 mL
10 mM 0.0156 mL 0.0778 mL 0.1555 mL 0.3888 mL
15 mM 0.0104 mL 0.0518 mL 0.1037 mL 0.2592 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Diranersen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diranersen2304711-06-4IONIS-MAPTRx BIIB080 ISIS 814907BIIB080BIIB 080BIIB-080ISIS814907ISIS 814907ISIS-814907Tau ProteinTauantisenseoligonucleotideAlzheimerDiseaseMAPTInhibitorinhibitorinhibit

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