PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene

Also Known as MBP; BMPG; MBP1; proMBP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 5553

About PRG2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,386,780-57,390,650 (from NCBI)

This gene has 4 transcripts (splice variants), 98 orthologues and 1 paralogue. Restricted expression toward placenta (RPKM 1164.9).

Summary

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), Angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

PRG2 Products (4)

mRNA Protein Name
NM_001243245.3 NP_001230174.1 bone marrow proteoglycan isoform 2 preproprotein
NM_001302926.2 NP_001289855.1 bone marrow proteoglycan isoform 1 preproprotein
NM_001302927.2 NP_001289856.1 bone marrow proteoglycan isoform 1 preproprotein
NM_002728.6 NP_002719.3 bone marrow proteoglycan isoform 1 preproprotein

PRG2 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (116 - 221)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

bone marrow proteoglycan

  • eosinophil granule major basic protein

PRG2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
PRG2 P13727 PAPPA Homo sapiens Q13219
GMS
12421832
Intra
PRG2 P13727 PAPPA Homo sapiens Q13219
Chromatography
7685339
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRG2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P7672 BMPG Protein, Human (HEK293, His) AAH05929.1 (L17-Y222 ) ≥ 95%, as determined by reducing SDS-PAGE.

PRG2 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811226 PRG2 Antibody WB, IHC-P, ICC/IF Human, Mouse

関連疾患

Diseases Alias
Hypereosinophilic Syndrome

  • Eosinophilia

  • HES

  • Eosinophilic Leukocytosis

  • Hypereosinophilic Syndrome, Idiopathic

  • Idiopathic Hypereosinophilic Syndrome

  • Disseminated Eosinophilic Collagen Disease

  • Eosinophilic Disorder

  • Disorders With Increased Eosinophil Counts
Dermatographia

  • Dermatographic Urticaria

  • Dermographism

  • Symptomatic Dermographism

  • Urticaria Factitia

  • Factitious Urticaria

  • Dermatographism
Conidiobolomycosis

  • Infection By Conidiobolus

  • Rhinoentomophthoromycosis

  • Entomophthoromycosis Conidiobolae
Esophagitis

  • Acute Esophagitis
Churg-Strauss Syndrome

  • Eosinophilic Granulomatosis With Polyangiitis

  • Allergic Granulomatous Angiitis

  • Churg-Strauss Vasculitis

  • Allergic Angiitis

  • Egpa

  • Granulomatous Allergic Angiitis

  • Allergic Granulomatosis Angiitis

  • Allergic Angiitis And Granulomatosis

  • Allergic Granulomatosis

  • Allergic Granulomatous And Angiitis

  • Css
Urticaria

  • Nettle Rash

  • Hives

  • Wheal

  • Urticaria Nos
Rhinitis

  • Runny Nose
Colon Sarcoma

  • Colonic Sarcoma
Loeffler Endocarditis

  • Eosinophilic Endomyocardial Disease

  • Eosinophilic Endocarditis

  • Loeffler'S Endocarditis

  • Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy
Pulmonary Eosinophilia

  • Asthmatic Pulmonary Eosinophilia

  • Eosinophilic Lung Infiltrate

  • Weingarten'S Syndrome
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Gastroenteritis

  • Cholera Morbus

  • Infectious Colitis, Enteritis And Gastroenteritis

  • Enteritis Due To Astrovirus

  • Rotaviral Gastroenteritis

  • Viral Gastroenteritis Due To Rotavirus
Schizophrenia 13

  • SCZD13

  • Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related

  • Schizophrenia, Susceptibility To, 13
Loeffler Syndrome

  • Loeffler'S Pneumonia

  • Loffler'S Syndrome

  • Simple Pulmonary Eosinophilia
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Endomyocardial Fibrosis

  • Becker'S Disease

  • Obscure African Cardiomyopathy

  • African Endomyocardial Fibrosis

  • Endomyocardial Sclerosis

  • EMF

  • Becker Muscular Dystrophy
Myiasis

  • Infestation By Fly Larvae

  • Infestation By Maggots

  • Maggot Infestation

  • Infestation By Larvae Of Flies

  • Infestation By Dermatobia

  • Infestation By Estrus Ovis

  • Infestation By Oestrus Ovis

  • Oestriasis

  • Oestrosis
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11088 PRG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11479 PXDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17666 Ptgr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19939 Prg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20464 Plpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26441 Prg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus PRG2 MGD MGI:103294
Rattus norvegicus PRG2 RGD RGD:69336
Others PRG2 NCBI