PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene
Also Known as MBP; BMPG; MBP1; proMBP
Species: Homo sapiens
About PRG2
This gene has 4 transcripts (splice variants), 98 orthologues and 1 paralogue. Restricted expression toward placenta (RPKM 1164.9).
Summary
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several Other proteins including pregnancy-associated plasma protein A (PAPPA), Angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PRG2 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001243245.3 | NP_001230174.1 | bone marrow proteoglycan isoform 2 preproprotein |
| NM_001302926.2 | NP_001289855.1 | bone marrow proteoglycan isoform 1 preproprotein |
| NM_001302927.2 | NP_001289856.1 | bone marrow proteoglycan isoform 1 preproprotein |
| NM_002728.6 | NP_002719.3 | bone marrow proteoglycan isoform 1 preproprotein |
PRG2 Protein Structure
Lectin_C: Lectin C-type domain (116 - 221)
- 0
- 100
- 200
- 222 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bone marrow proteoglycan |
|
PRG2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PRG2 | P13727 | PAPPA | Homo sapiens | Q13219 | 12421832 | |
|
Intra
|
PRG2 | P13727 | PAPPA | Homo sapiens | Q13219 | 7685339 |
Recombinant PRG2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7672 | BMPG Protein, Human (HEK293, His) | AAH05929.1 (L17-Y222 ) | ≥ 95%, as determined by reducing SDS-PAGE. |
PRG2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811226 | PRG2 Antibody | WB, IHC-P, ICC/IF | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypereosinophilic Syndrome |
|
|
| Dermatographia |
|
|
| Conidiobolomycosis |
|
|
| Esophagitis |
|
|
| Churg-Strauss Syndrome |
|
|
| Urticaria |
|
|
| Rhinitis |
|
|
| Colon Sarcoma |
|
|
| Loeffler Endocarditis |
|
|
| Pulmonary Eosinophilia |
|
|
| Asthma |
|
|
| Gastroenteritis |
|
|
| Schizophrenia 13 |
|
|
| Loeffler Syndrome |
|
|
| Dermatitis, Atopic |
|
|
| Endomyocardial Fibrosis |
|
|
| Myiasis |
|
|
| Esophagitis, Eosinophilic, 1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11088 | PRG2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS11479 | PXDN Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS17666 | Ptgr2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19939 | Prg2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS20464 | Plpp3 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS26441 | Prg2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | PRG2 | MGD | MGI:103294 |
| Rattus norvegicus | PRG2 | RGD | RGD:69336 |
| Others | PRG2 | NCBI |
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