Harzianic acid
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 157148-06-6
- 分子式: C19H27NO6
- 分子量:365.42
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
Acetohydroxyacid synthase (AHAS)[2]
体外実験
Harzianic acid shows significant antimicrobial activity against MRSP and MSSP, with MIC values of 32 μg/mL and 16 μg/mL, respectively[1].
Harzianic acid (8-128 μg/mL) exhibits low cytotoxicity on HaCaT cells[1].
Harzianic acid inhibits fungal ThAHAS as a competitive inhibitor with a Ki of 6.65 μM[2].
Harzianic acid (0.1-100 μg/mL) inhibits pathogenic fungi growth[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 157148-06-6
-
分子量 365.42
-
分子式 C19H27NO6
-
SMILES
CC(C)[C@@](C(O)=O)(O)C[C@H](N1C)C(/C(C1=O)=C(O)\C=C\C=C\CCC)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. [Content Brief]
[2]. Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Harzianic acid 関連分類
HY-122950 関連分類
Powered by Bioz