NLRP3-IN-9
NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2768759-64-2
- 分子式: C16H19N2NaO5S
- 分子量:374.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
NLRP3 |
体外実験
NLRP3-IN-9 (compound 4b) (0.01-3 µM) inhibits IL-1β release in a dose-dependent manner in ATP (5 mM) and LPS (1 µg/mL)-induced macrophages[1].
NLRP3-IN-9 (1 µM; 15 min) inhibits NLRP3 inflammasome oligomerization[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Macrophages
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Concentration:1 µM
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Incubation Time:15 min
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Result:Inhibited teh expression of IL-1β P17, Casp-1 p10 peotein levelwith the ATP (5 mM) and LPS (1 µg/mL)-induced in the supernatant of the cultures, without affecting the intracellular levels of their precursors.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:3-4 month old male and female C57BL/6J WT and NLRP3-KO mice[1]
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Dosage:3, 10 mg/kg
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Administration:I.p.
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Result:Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
化学情報
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CAS 番号 2768759-64-2
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分子量 374.39
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分子式 C16H19N2NaO5S
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SMILES
O=C(N([Na])S(C1=CC(C(C)(O)C)=CO1)(=O)=O)NC2=CC(C)=CC(C)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NLRP3-IN-9 関連分類
HY-146802 関連分類
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