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製品番号: HY-151506

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Phospholipid PL1

Name: Phospholipid PL1
Brand: MedChemExpress
SKU: HY-151506
Price: 522.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2274812-94-9
分子式: C₆₁H₁₂₁N₂O₁₀P
分子量:1073.59

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Phospholipid PL1 構造式

CAS 番号: 2274812-94-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体内実験

Phospholipid PL1 (10 μg mRNA/mouse; i.t.; 6 times every other day; for 60 d) improves the immunotherapy with an anti-CD137 Ab and antitumor activity with an anti-OX40 Ab in tumor models with better results obtained in the B16F10 melanoma model than the A20 lymphoma model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16F10 melanoma mouse model and A20 lymphoma mouse model (C57BL/6 mice)^[1]
Dosage:

Administration of PL1-CD137 + anti-CD137 Ab; PL1-CD137 (10 µg mRNA/mouse), and anti-CD137 Ab (16 µg/mouse)
Administration:

Intratumoral injection; 6 times every other day; 60 days
Result:

Dramatically decreased the tumor growth rate by 5-fold (18 days after inoculation), and increased the overall survival time in B16F10 melanoma model.
Resulted in a 2-fold decrease in the tumor growth rate (18d after inoculation) in A20 lymphoma model, without significant extension in the overall survival time.

Animal Model:

B16F10 melanoma mouse model and CT26 colon carcinoma mouse model (C57BL/6 mice)^[1]
Dosage:

Administration of PL1-OX40 + anti-OX40 Ab; PL1-OX40 (10 µg mRNA/mouse), and anti-OX40 Ab (8 µg/mouse)
Administration:

Intratumoral injection; 6 times every other day; 60 days
Result:

Significantly decreased the tumor growth and prolonged survival in comparison to treatment with PBS and PL1-OX40 + anti-OX40 Ab in both tumor models.

化学情報

CAS 番号 2274812-94-9
分子量 1073.59
分子式 C₆₁H₁₂₁N₂O₁₀P
SMILES

O=C(CCCCCCCCN(CCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)CCCOP(OCC)(OCC)=O)OC(CCCCC)CC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Li W, et al. Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy. Nat Commun. 2021 Dec 14;12(1):7264. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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