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製品番号: HY-N11008

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Physagulide J

Physagulide J is a kind of withanolides compound that can be isolated from Physalis angulata L.. Many kinds of active ingredients of Physalis angulata L. shows anti-inflammatory and anti-tumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1496524-09-4
分子式: C₃₀H₄₀O₇
分子量:512.63

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Physagulide J 構造式

CAS 番号: 1496524-09-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	0.39 μM Compound: 17	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
A498	IC₅₀	0.71 μM Compound: 17	Antiproliferative activity against human A498 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human A498 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
ACHN	IC₅₀	0.73 μM Compound: 17	Antiproliferative activity against human ACHN cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human ACHN cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
CWR22R	IC₅₀	0.9 μM Compound: 17	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
LNCaP C4-2B	IC₅₀	0.49 μM Compound: 17	Antiproliferative activity against human C4-2B cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay Antiproliferative activity against human C4-2B cells assessed as inhibition of cell viability after 48 hrs by MTT reduction assay	[PMID: 27295506]
RAW264.7	IC₅₀	1.36 μM Compound: 17	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 27295506]

化学情報

CAS 番号 1496524-09-4
分子量 512.63
分子式 C₃₀H₄₀O₇
SMILES

CC(C[C@H]([C@H]([C@H]1C[C@@H]([C@]2([C@@H]3C[C@H]4O[C@]45CC=CC([C@@]5([C@H]3CC[C@@]21C)C)=O)O)OC(C)=O)C)O6)=C(C)C6=O
Structure Classification
- Steroids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Signal Pathway Related

Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sun CP, et al. Antiproliferative and Anti-inflammatory Withanolides from Physalis angulata. J Nat Prod. 2016 Jun 24;79(6):1586-97. [Content Brief]

[2]. 孙成鹏. 苦蘵的化学成分及其抗肿瘤和抗炎活性研究. 沈阳药科大学, 2016.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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