Rosopatamab
Based on 1 Customer Validation
Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 (177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.47%
- CAS 番号: 2260767-49-3
- 分子量:144.11 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
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生物活性
Human IgG1 kappa
Human
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FOLH1/PSMA |
RDC Antibody |
177Lu-rosopatamab (anti-PSMA) (6 MBq, i.v., single) plus Peposertib (HY-101570) has 75% complete response (3/4) vs 25% complete response (1/4) in the 177Lu-anti-PSMA (6MBq) alone arm in the prostate BALB/c nude mice model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized PSMA Protein, Human (HEK293, His, HY-P70548A) can bind Rosopatamab. The EC50 for this effect is 88.78 ng/mL.
化学情報
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CAS 番号 2260767-49-3
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性状 Liquid
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分子量 144.11 kDa
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Color Colorless to light yellow
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SMILES
[Rosopatamab]
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別名
HUJ-591; TLX591
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)