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製品番号: HY-12476

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SAR156497

SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC₅₀ value of 4 μM. SAR156497 can be used in anticancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1256137-14-0
分子式: C₂₇H₂₄N₄O₄
分子量:468.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SAR156497 構造式

CAS 番号: 1256137-14-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

PDE3

4 μM (IC₅₀)

Aurora A

0.6 nM (IC₅₀)

Aurora B

1 nM (IC₅₀)

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示 :

Aurora Kinase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	3.714 μM Compound: SAR156497	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HEK293	IC₅₀	5.864 μM Compound: SAR156497	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	0.00611 μM Compound: SAR156497	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	67 nM Compound: 47	Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis	[PMID: 25369539]
PBMC	IC₅₀	>10 μM Compound: 47	Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay	[PMID: 25369539]
PC-3	IC₅₀	12.58 μM Compound: SAR156497	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]

化学情報

CAS 番号 1256137-14-0
分子量 468.50
分子式 C₂₇H₂₄N₄O₄
SMILES

O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Carry JC, et al. SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem. 2015 Jan 8;58(1):362-75. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
CAS 番号:
生物種:
純度:
数量:

SAR156497

Alisertib

Barasertib

Barasertib-HQPA

Reversine

Tozasertib

MK-5108

GSK-1070916

ZM-447439

Hesperadin

AMG 900

LY3295668

MLN8054

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示

Aurora Kinase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

SAR156497

Alisertib

Barasertib

Barasertib-HQPA

Reversine

Tozasertib

MK-5108

GSK-1070916

ZM-447439

Hesperadin

AMG 900

LY3295668

MLN8054

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示

Aurora Kinase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

SAR156497 関連分類

HY-12476 関連分類

Bioz