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United States

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製品番号: HY-183722

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SDH-IN-46

SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₈H₁₃F₅N₄O
分子量:396.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SDH-IN-46 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SDH-IN-46 (Compound 6i) (20 μg/mL) inhibits mycelial growth of Rhizoctonia solani, Sclerotinia sclerotiorum, Valsa mali, Fusarium graminearum, and Botrytis cinerea by 66.2-92.4%^[1].
SDH-IN-46 potently inhibits mycelial growth of Sclerotinia sclerotiorum with an EC₅₀ of 0.44 μg/mL, and inhibits Rhizoctonia solani, Valsa mali, Fusarium graminearum, and Botrytis cinerea with EC₅₀ values ranging from 1.05-5.41 μg/mL^[1].
SDH-IN-46 potently inhibits Sclerotinia sclerotiorum succinate dehydrogenase with an IC₅₀ of 1.21 μM^[1].
SDH-IN-46 (1 μg/mL) causes significant structural damage to Sclerotinia sclerotiorum hyphae, including wrinkling, shrinkage, and rupture^[1].
SDH-IN-46 (100 μg/mL) shows protective efficacy against S. sclerotiorum on oilseed rape leaves, R. solani on rice leaves, and V. mali on apple fruits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

分子量 396.31
分子式 C₁₈H₁₃F₅N₄O
SMILES

O=C(NC1=CN(C)N=C1C(F)F)C2=CC=CC=C2NC3=CC(F)=C(F)C(F)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Luo B, et al. Design and Synthesis of Novel N-(Pyrazol-4-yl)benzamide Derivatives Featuring a Diphenylamine or Diphenyl Ether Scaffold as Potential Broad-Spectrum SDH Inhibitors. J Agric Food Chem. 2026;74(18):14263-14274. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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