製品番号: HY-163469

SRC-3-IN-2

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Based on 1 Customer Validation

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 96.32%
CAS 番号: 3074959-44-4
分子式: C₁₅H₁₂F₃N₅
分子量:319.28

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

SRC-3-IN-2 構造式

CAS 番号: 3074959-44-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 (SRC-3) inhibitor. SRC-3-IN-2 has antitumor activity^[1].

Src アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	0.8 nM Compound: SI-12 (6c)	Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
Hepatocyte	IC₅₀	>1000 nM Compound: SI-12 (6c)	Cytotoxicity against CD-1 mouse Primary hepatocyte assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against CD-1 mouse Primary hepatocyte assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
HPAC	IC₅₀	26 nM Compound: SI-12 (6c)	Cytotoxicity against human HPAC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human HPAC cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
LNCaP	IC₅₀	25 nM Compound: SI-12 (6c)	Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
MCF7	IC₅₀	3.4 nM Compound: SI-12 (6c)	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
MDA-MB-468	IC₅₀	15 nM Compound: SI-12 (6c)	Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	119 nM Compound: SI-12 (6c)	Cytotoxicity against SiRNA mediated SRC-3.2 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against SiRNA mediated SRC-3.2 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	147 nM Compound: SI-12 (6c)	Cytotoxicity against SiRNA mediated SRC-3.1 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against SiRNA mediated SRC-3.1 knockdown human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	25.2 nM Compound: SI-12 (6c)	Cytotoxicity against human PANC-1 cells mediated with siRNA control assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells mediated with siRNA control assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]
PANC-1	IC₅₀	29 nM Compound: SI-12 (6c)	Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 38551814]

体外実験

SRC-3-IN-2 IC₅₀ value of MCF7 cell is 3.4 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Pharmacokinetic Analysis in CD-1 mice Model^[1]

Route	Dose (mg/kg)	AUC_last (ng·h/mL)	t_1/2 (h)	T_max (h)	C_max (ng/mL)	Cl_obs (mL·min/kg)	F (%)
i.v.	1	737	22.5	0.033	1066	22	/
p.o.	10	1719	14.3	0.25	217	/	24.6

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3074959-44-4
性状 Solid
分子量 319.28
分子式 C₁₅H₁₂F₃N₅
Color Purple to purplish red
SMILES

CN1C2=CC(F)=C(F)C=C2N/C1=N\N=C(C3=CC=C(C=N3)F)/C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (78.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1320 mL

15.6602 mL

31.3205 mL

5 mM

0.6264 mL

3.1320 mL

6.2641 mL

10 mM

0.3132 mL

1.5660 mL

3.1320 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lu D, et al. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Mar 29. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1320 mL	15.6602 mL	31.3205 mL	78.3012 mL
	5 mM	0.6264 mL	3.1320 mL	6.2641 mL	15.6602 mL
	10 mM	0.3132 mL	1.5660 mL	3.1320 mL	7.8301 mL
	15 mM	0.2088 mL	1.0440 mL	2.0880 mL	5.2201 mL
	20 mM	0.1566 mL	0.7830 mL	1.5660 mL	3.9151 mL
	25 mM	0.1253 mL	0.6264 mL	1.2528 mL	3.1320 mL
	30 mM	0.1044 mL	0.5220 mL	1.0440 mL	2.6100 mL
	40 mM	0.0783 mL	0.3915 mL	0.7830 mL	1.9575 mL
	50 mM	0.0626 mL	0.3132 mL	0.6264 mL	1.5660 mL
	60 mM	0.0522 mL	0.2610 mL	0.5220 mL	1.3050 mL

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SRC-3-IN-2

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Src アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SRC-3-IN-2

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Angiogenesis-Related Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Src アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SRC-3-IN-2 関連分類

HY-163469 関連分類