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製品番号: HY-N21685

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Uralione D

Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1927024-52-9
分子式: C₃₈H₅₂O₇
分子量:620.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Uralione D 構造式

CAS 番号: 1927024-52-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MKN-45	IC50	18.47 μM	Cytotoxicity against human MKN-45 gastric cancer cells assessed as reduction in cell viability incubated for 24 h by Cell Counting Kit-8 (CCK-8) assay. Cytotoxicity against human MKN-45 gastric cancer cells assessed as reduction in cell viability incubated for 24 h by Cell Counting Kit-8 (CCK-8) assay.	slct.202504003

体外実験

Uralione D (compound 4) (0.1-10.0 μM; 48 h) protects PC12 cells from Corticosterone (HY-B1618)-induced injury, with cell viabilities ranging from 72.5% to 80.9% across 0.1-10.0 μM concentrations after 48 h of co-incubation^[1].
Uralione D (compound 5) (24 h) exerts potent cytotoxicity against human MKN-45 gastric cancer cells, with an IC₅₀ value of 18.47 µM after 24 h of treatment^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

0.1, 0.3, 1.0, 3.0, 10.0 μM
Incubation Time:

48 h
Result:

Exhibited significant protective effects against corticosterone-induced PC12 cell injury at all tested concentrations.
Showed cell viability of 77.9% at 0.1 μM relative to untreated control set at 100%.
Showed cell viability of 77.7% at 0.3 μM relative to untreated control set at 100%.
Showed cell viability of 78.5% at 1.0 μM relative to untreated control set at 100%.
Showed cell viability of 72.5% at 3.0 μM relative to untreated control set at 100%.
Showed cell viability of 80.9% at 10.0 μM relative to untreated control set at 100%.
Achieved the highest viability at 10.0 μM.

化学情報

CAS 番号 1927024-52-9
分子量 620.82
分子式 C₃₈H₅₂O₇
SMILES

O=C(C1=CC=CC=C1)[C@]23C4=C(C[C@@H](C(C)(O4)C)O)C([C@](C2=O)(C[C@@H]([C@@]3(C)CC/C=C(C)/C)C/C=C(C)\C)C[C@H](O)C(C)(O)C)=O
Structure Classification
- Terpenoids
- Other Monoterpenes
- Ketones, Aldehydes, Acids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhou ZB, et al. Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A. Journal of natural products. 2016 May 27;79(5):1231-40.

[2]. Lou HY, et al. Hyperkouytones A-O, new polyprenylated acylphloroglucinols from Hypericum kouytchense with multidrug resistance reversal activity. Chin J Chem. 2024;42(24):3293-3307.

[3]. Jing C, et al. Polycyclic polyprenylated acylphloroglucinols (PPAPs) kouytchin A‑B and a tetramethoxydibenzo[1,4]dioxin from Hypericum kouytchense: isolation and cytotoxic evaluation. ChemistrySelect. 2026;11(1):e04003.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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