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製品番号: HY-147792

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WNY1613

WNY1613 is a potent and selective PI3Kδ inhibitor with piperazinone-containing purine scaffold. WNY1613 induces cancer cell apoptosis and inhibits the phosphorylation of PI3K downstream components in NHL cell lines. WNY1613 exhibits anti-NHL activity in vitro and in vivo.

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CAS 番号: 2650546-39-5
分子式: C₂₉H₃₅N₉O₃
分子量:557.65

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WNY1613 構造式

CAS 番号: 2650546-39-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PI3K アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Granta-519	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
JeKo-1	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
NAMALVA	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
OCI-Ly3	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SUD4	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SU-DHL-6	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
WSUDLCL2	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]

化学情報

CAS 番号 2650546-39-5
分子量 557.65
分子式 C₂₉H₃₅N₉O₃
SMILES

O=C1N(CC2=NC3=C(N4CCOCC4)N=C(N5C6=CC=CC=C6N=C5CC)N=C3N2C)CCN(C(C7CCC7)=O)C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zuo WQ, et al. Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma. Bioorg Chem. 2020;105:104344. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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