Pim1 - proviral integration site 1 Gene

Also Known as Pim-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18712

About Pim1

Chromosome 17: 29,709,727-29,715,086 forward strand.GRCm39:CM001010.3

This gene has 7 transcripts (splice variants), 245 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in adrenal adult (RPKM 59.9), duodenum adult (RPKM 47.) and 24 other tissues.

Summary

Enables ATP binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of brown fat cell differentiation; protein stabilization; and regulation of hematopoietic stem cell proliferation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; primitive streak; and spleen. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pim1 Products (2)

mRNA Protein Name
NM_008842.4 NP_032868.2 serine/threonine-protein kinase pim-1 isoform 1
NM_001364913.1 NP_001351842.1 serine/threonine-protein kinase pim-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
1825810 MGI
enables manganese ion binding IDA
IDA: Inferred from direct assay
1825810 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18438430 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
1825810 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18438430 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
27923061 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
1825810 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
18438430 MGI
involved in regulation of hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
23495171 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pim1 Protein Structure

PKc_like

PKc_like: cl21453 (36 - 289)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-1

  • proto-oncogene serine/threonine-protein kinase pim-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101870 Uzansertib Inhibitor 99.45% Phase 2
HY-19322 PIM447 Inhibitor 99.52% Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10371 Pim1/AAK1-IN-1 Inhibitor 98.40% Unkown
HY-16576A SMI-4a Inhibitor 99.85% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-19322B PIM-447 dihydrochloride Inhibitor 99.82% Unkown
HY-18086 TCS PIM-1 1 Inhibitor 98.40% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-135906 CK2/ERK8-IN-1 Inhibitor 99.0% Unkown
HY-101947 SMI-16a Inhibitor 98.0% Unkown
HY-101870B Uzansertib phosphate Inhibitor 99.77% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-147785 Pim-1 kinase inhibitor 2 Inhibitor 99.91% Unkown
HY-108605 PIM1-IN-2 Inhibitor 99.0% Unkown
HY-142696A CDK6/PIM1-IN-1 hydrochloride Inhibitor 99.38% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-149054 GSK-3β inhibitor 13 Inhibitor 99.74% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-123983 HS56 Inhibitor 99.6% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-156470 Multi-kinase-IN-6 Inhibitor / Unkown
HY-185446 KZ-02 Inhibitor / Unkown
HY-150731 Pim-1 kinase inhibitor 3 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-135816 CK2/PIM1-IN-1 Inhibitor / Unkown
HY-178133 Pim-1 kinase-IN-14 Inhibitor / Unkown
HY-168479 VB1080 Inhibitor / Unkown
HY-173224 CDK2/PIM1-IN-1 Inhibitor / Unkown
HY-186146 SGI-1776-VHL-02 Degrader 96.67% Unkown
HY-147920 PIM1-IN-6 Inhibitor / Unkown
HY-168071 Pim-1 kinase inhibitor 11 Inhibitor / Unkown
HY-147921 PIM1-IN-7 Inhibitor / Unkown
HY-179098 Multi-target kinase-IN-8 Inhibitor / Unkown
HY-143898 PIM1-IN-4 Inhibitor / Unkown
HY-143897 PIM1-IN-3 Inhibitor / Unkown
HY-168517 PIM-1/CK2-IN-2 Inhibitor / Unkown
HY-178443 Pim-1 kinase-IN-15 Inhibitor / Unkown
HY-181925 FD2024 Inhibitor / Unkown
HY-122670 VS-II-173 Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-181125 Pim-1 kinase-IN-16 Inhibitor / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown
HY-184811 PIM-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pim1 NCBI NCBI:5292