CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

Also Known as Cyp19; Cyp19a; p450arom; Aromatase

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25147

About CYP19A1

Primary_assembly 8: 54,553,165-54,580,758 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 319 orthologues, 17 paralogues and is associated with 48 phenotypes. Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues.

Summary

Enables aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP19A1 Products (1)

mRNA Protein Name
NM_017085.3 NP_058781.2 aromatase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aromatase activity IDA
IDA: Inferred from direct assay
16269516 RGD
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: Inferred from direct assay
11850226 RGD
Biological Process GO Annotation Evidence References Source
involved in C21-steroid hormone metabolic process IDA
IDA: Inferred from direct assay
19190754 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
8097866 RGD
involved in androgen metabolic process IMP
IMP: Inferred from mutant phenotype
19492405 RGD
involved in bile acid metabolic process IEP
IEP: Inferred from expression pattern
20026603 RGD
involved in biphenyl metabolic process IEP
IEP: Inferred from expression pattern
19464308 RGD
involved in bone development IEP
IEP: Inferred from expression pattern
15012600 RGD
involved in calcineurin-mediated signaling IMP
IMP: Inferred from mutant phenotype
25057110 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
20434519 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
20810564 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
18353182 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
16569475 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: Inferred from expression pattern
21047944 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
20059580 RGD
involved in estrogen biosynthetic process IDA
IDA: Inferred from direct assay
19665544 RGD
involved in granulocyte differentiation IEP
IEP: Inferred from expression pattern
18401763 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21047951 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
15804399 RGD
involved in luteinization IEP
IEP: Inferred from expression pattern
23183184 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
20554652 RGD
involved in melatonin metabolic process IEP
IEP: Inferred from expression pattern
17700567 RGD
involved in negative regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
8694895 RGD
involved in phthalate metabolic process IEP
IEP: Inferred from expression pattern
20920559 RGD
involved in regulation of synapse structure or activity IMP
IMP: Inferred from mutant phenotype
17005180 RGD
involved in response to cesium ion IEP
IEP: Inferred from expression pattern
20451883 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
21115103 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
19734697 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
21126571 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
18821396 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
20708649 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20821433 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16569475 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19497980 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
14694190 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
14694190 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19565659 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
14694190 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
20926671 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP19A1 Protein Structure

CYP19A1

CYP19A1: cd20616 (71 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

aromatase

  • CYPXIX

  • Cytochrome P450, 19, aromatase

  • P-450AROM

  • cytochrome P-450AROM

  • cytochrome P450 19A1

  • cytochrome P450 19A1-like

  • cytochrome P450 family 19 subfamily a

  • cytochrome P450, subfamily 19

  • estrogen synthase

  • estrogen synthetase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113986 Dexfadrostat Inhibitor 98.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133668 Monoethyl phthalate Activator 98.58% Unkown
HY-150775 CYP19A1-IN-2 Inhibitor 99.31% Unkown
HY-133668S Monoethyl phthalate-d4 Activator 98.36% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% Unkown
HY-N9551 Eriodictyol chalcone Inhibitor 97.25% Unkown
HY-113986C Dexfadrostat hydrochloride Inhibitor / Unkown
HY-122744 CYP11B1-IN-1 Inhibitor / Unkown
HY-173279 CYP19A1-IN-1 Inhibitor / Unkown
HY-181163 Caspase-3/7 activator 4 / Unkown
HY-RS03438 CYP19A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03439 Cyp19a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03440 CYP19A1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z4488 5-Dibromomethyl anastrozole Control / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP19A1 NCBI NCBI:1588