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Cat. No.: HY-183450

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Supradamal

Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC₅₀ of 83 nM against *Plasmodium falciparum* and an IC₅₀ of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.

For research use only. We do not sell to patients.

CAS No.: 71458-51-0
Formula: C₁₇H₂₁N₃O₂
Molecular Weight:299.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Supradamal Chemical Structure

CAS No.: 71458-51-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Parasite Isoforms :

In Vitro

Supradamal inhibits the growth of Plasmodium falciparum in human red blood cells, including the development of trophozoites^[1].
Supradamal (Compound 4a) inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium falciparum FKBD35, with an IC₅₀ of 83 nM^[3].
Supradamal inhibits the peptidyl-prolyl isomerase activity of purified Plasmodium vivax FKBD35 with an IC₅₀ of 75 nM^[3].
Supradamal (48 h) inhibits the growth of *Plasmodium falciparum* strain 3D7 in vitro by specifically interfering with the development of the trophozoite stage, while exerting no effect on ring-stage parasites^[3].
Supradamal (500 nM; 4-16 h) specifically inhibits the development of trophozoite-stage parasites of the Plasmodium falciparum 3D7 strain, with no effect on ring-stage or schizont-stage parasites^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 71458-51-0
Molecular Weight 299.37
Formula C₁₇H₂₁N₃O₂
SMILES

O=C(C1=CC=NC=C1)NNC(C23CC4CC(C3)CC(C2)C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yoon, H.S., et al. Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics. Malar J 9 (Suppl 2), P60 (2010).

[2]. Rasch J, et al. Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila. Frontiers in bioengineering and biotechnology. 2015;3:41.

[3]. Harikishore A, et al. Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS medicinal chemistry letters. 2013 Nov 14;4(11):1097-101.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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