71458-51-0
71458-51-0
Chemical Structure
Supradamal
- CAS No.: 71458-51-0
- Formula:C17H21N3O2
- Molecular Weight:299.37
InChIKey: VXKCGGYPMLXZKG-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NNC(C23CC4CC(C3)CC(C2)C4)=O
Biological Activity: Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research[1][2][3].
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Supradamal | Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research. | |||||||||||||||||||||
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References
- [1]. Yoon, H.S., et al. Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics. Malar J 9 (Suppl 2), P60 (2010).
- [2]. Rasch J, et al. Novel Cycloheximide Derivatives Targeting the Moonlighting Protein Mip Exhibit Specific Antimicrobial Activity Against Legionella pneumophila. Frontiers in bioengineering and biotechnology. 2015;3:41. [Content Brief]
- [3]. Harikishore A, et al. Adamantyl derivative as a potent inhibitor of Plasmodium FK506 binding protein 35. ACS medicinal chemistry letters. 2013 Nov 14;4(11):1097-101. [Content Brief]
Keywords
