Citric acid tripotassium hydrate
Based on 13 publication(s) in Google Scholar
Citric acid tripotassium hydrate (Potassium citrate monohydrate) is a natural preservative and food tartness enhancer. Citric acid tripotassium hydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid tripotassium hydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid tripotassium hydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
- CAS No.: 6100-05-6
- 화학식: C6H7K3O8
- 분자량:324.41
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-W009156R
Citric acid tripotassium hydrate (Standard)
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Publications Citing Use of MedChemExpress (MCE) Citric acid tripotassium hydrate
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Mol Cancer. 2025 Oct 2;24(1):238. [Abstract]
- J Exp Clin Cancer Res. 2025 Jul 8;44(1):195. [Abstract]
- Cell Rep Med. 2026 Feb 17;7(2):102621. [Abstract]
- Food Chem. 2025 Oct 15:489:144992. [Abstract]
- Food Chem. 2023 Mar 30;405(Pt A):134807. [Abstract]
- Food Res Int. 2026 Feb 6.
- Regen Biomater. 2024 Aug 22:11:rbae098. [Abstract]
- Life Sci. 2024 Jun 15:347:122682. [Abstract]
- BMC Complement Med Ther. 2026 Apr 2;26(1):177. [Abstract]
- Bone. 2025 Apr:193:117411. [Abstract]
- J Sep Sci. 2025 Nov;48(11):e70312. [Abstract]
- New J Chem. 03 Aug 2022.
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
Citric acid (0-12.5 mM; 24 h) tripotassium hydrate shows antiproliferative activity in a dose dependent manner[3].
Citric acid (12.5 mM; 72 h) tripotassium hydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Citric acid (12.5 mM; 48 h) tripotassium hydrate increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT cells
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Concentration:0, 2.5, 5, 7.5, 10, 12.5 mM
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Incubation Time:24 h
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Result:Inhibited the cell viability in a dose dependent manner.
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Cell Line:HaCaT cells
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Concentration:12.5 mM
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Incubation Time:0, 12, 24, 48, 72 h
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Result:Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dose-dependent manner.
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Cell Line:HaCaT cells
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Concentration:12.5 mM
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Incubation Time:12, 24, 48, 72 h
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Result:Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
Citric acid (120, 240, and 480 mg/kg; i.p.) tripotassium hydrate induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Citric acid (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) tripotassium hydrate causes renal toxicity in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20 g male Kunming mice[2]
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Dosage:120, 240, 480 mg/kg
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Administration:i.p.; weekly for 3 weeks
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Result:T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
Chemical Information
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CAS No. 6100-05-6
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Appearance Solid
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분자량 324.41
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화학식 C6H7K3O8
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Color White to off-white
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SMILES
O=C(O[K])CC(C(O[K])=O)(O)CC(O[K])=O.O
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Synonyms
Potassium citrate monohydrate
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Mol Cancer
Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization. [Abstract]2025 Oct 2;24(1):238. PMID: 41039575 -
J Exp Clin Cancer Res
Genomic profiling of a collection of patient-derived xenografts and cell lines identified ixabepilone as an active drug against chemo-resistant osteosarcoma. [Abstract]2025 Jul 8;44(1):195. PMID: 40624718 -
Cell Rep Med
Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer. [Abstract]2026 Feb 17;7(2):102621. PMID: 41707647 -
Food Chem
Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]2025 Oct 15:489:144992. PMID: 40466530 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
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Regen Biomater
Polyzwitterion-grafted decellularized bovine intercostal arteries as new substitutes of small-diameter arteries for vascular regeneration. [Abstract]2024 Aug 22:11:rbae098. PMID: 39224131 -
Life Sci
Homogentisic acid metabolism inhibits papillary thyroid carcinoma proliferation through ROS and p21-induced cell cycle arrest. [Abstract]2024 Jun 15:347:122682. PMID: 38702025 -
BMC Complement Med Ther
Hepatotoxicity prediction for traditional Chinese medicine: a two-step in silico framework integrating network and machine learning approaches. [Abstract]2026 Apr 2;26(1):177. PMID: 41923057 -
Bone
The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS. [Abstract]2025 Apr:193:117411. PMID: 39884488 -
J Sep Sci
Cell Metabolomics Reveals the Hepatotoxic Mechanism of Copper in Normal Rat Liver Cells Using Reversed-Phase and Hydrophilic Interaction Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry. [Abstract]2025 Nov;48(11):e70312. PMID: 41172059 -
용액&용해도
H2O : 120 mg/mL (369.90 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (308.25 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [Content Brief]
[2]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan;90(1):38-44. [Content Brief]
[3]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. [Content Brief]
[4]. Ciriminna R, et al. Citric acid: emerging applications of key biotechnology industrial product. Chem Cent J. 2017 Mar 8;11:22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.0825 mL | 15.4126 mL | 30.8252 mL | 77.0630 mL |
| 5 mM | 0.6165 mL | 3.0825 mL | 6.1650 mL | 15.4126 mL | |
| 10 mM | 0.3083 mL | 1.5413 mL | 3.0825 mL | 7.7063 mL | |
| 15 mM | 0.2055 mL | 1.0275 mL | 2.0550 mL | 5.1375 mL | |
| 20 mM | 0.1541 mL | 0.7706 mL | 1.5413 mL | 3.8531 mL | |
| 25 mM | 0.1233 mL | 0.6165 mL | 1.2330 mL | 3.0825 mL | |
| 30 mM | 0.1028 mL | 0.5138 mL | 1.0275 mL | 2.5688 mL | |
| 40 mM | 0.0771 mL | 0.3853 mL | 0.7706 mL | 1.9266 mL | |
| 50 mM | 0.0617 mL | 0.3083 mL | 0.6165 mL | 1.5413 mL | |
| 60 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL | |
| 80 mM | 0.0385 mL | 0.1927 mL | 0.3853 mL | 0.9633 mL | |
| 100 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7706 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Citric acid tripotassium hydrate Related Classifications
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