Metoprolol-d7
Based on 1 Customer Validation
Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.00%
- CAS No.: 959787-96-3
- 화학식: C15H18D7NO3
- 분자량:274.41
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
All Adrenergic Receptor Isoforms
More
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 959787-96-3
-
Unlabeled CAS 51384-51-1
-
Appearance Solid
-
분자량 274.41
-
화학식 C15H18D7NO3
-
Color White to off-white
-
SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(O)COC1=CC=C(C=C1)CCOC
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 100 mg/mL (364.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (269 KB)
-
SDS (563 KB)
- English - EN (563 KB)
- Français - FR (563 KB)
- Deutsch - DE (563 KB)
- Norwegian - NO (563 KB)
- Español - ES (563 KB)
- Swedish - SV (563 KB)
- Italian - IT (563 KB)
- Korean - KR (563 KB)
- Portuguese - PT (563 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Benfield P, et al. Metoprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in hypertension, ischaemic heart disease and related cardiovascular disorders. Drugs. 1986 May;31(5):376-429. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6442 mL | 18.2209 mL | 36.4418 mL | 91.1046 mL |
| 5 mM | 0.7288 mL | 3.6442 mL | 7.2884 mL | 18.2209 mL | |
| 10 mM | 0.3644 mL | 1.8221 mL | 3.6442 mL | 9.1105 mL | |
| 15 mM | 0.2429 mL | 1.2147 mL | 2.4295 mL | 6.0736 mL | |
| 20 mM | 0.1822 mL | 0.9110 mL | 1.8221 mL | 4.5552 mL | |
| 25 mM | 0.1458 mL | 0.7288 mL | 1.4577 mL | 3.6442 mL | |
| 30 mM | 0.1215 mL | 0.6074 mL | 1.2147 mL | 3.0368 mL | |
| 40 mM | 0.0911 mL | 0.4555 mL | 0.9110 mL | 2.2776 mL | |
| 50 mM | 0.0729 mL | 0.3644 mL | 0.7288 mL | 1.8221 mL | |
| 60 mM | 0.0607 mL | 0.3037 mL | 0.6074 mL | 1.5184 mL | |
| 80 mM | 0.0456 mL | 0.2278 mL | 0.4555 mL | 1.1388 mL | |
| 100 mM | 0.0364 mL | 0.1822 mL | 0.3644 mL | 0.9110 mL |
Metoprolol-d7 Related Classifications
HY-17503S Related Classifications
Powered by Bioz