Molidustat sodium
Based on 8 publication(s) in Google Scholar
Molidustat sodium is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat sodium can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat sodium can be utilized in the research of renal anemia.
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- CAS No.: 1375799-59-9
- 화학식: C13H13N8NaO2
- 분자량:336.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Molidustat sodium
More- Immunity. 2026 Feb 18:S1074-7613(26)00035-X. [Abstract]
- Cell Rep. 2021 Apr 20;35(3):109020. [Abstract]
- iScience. 2021 Sep 25;24(10):103170. [Abstract]
- Microb Pathog. 2026 Apr:213:108291. [Abstract]
- J Pharm Biomed Anal. 2021 Feb 20:195:113870. [Abstract]
- Drug Test Anal. 2025 May;17(5):647-654. [Abstract]
- Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
- bioRxiv. 2023 Nov 2.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
Biological Activity
제품 설명
IC50 & Target
IC50: 480 nM (PHD1), 280 nM (PHD2), 450 nM (PHD3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.28 μM
Compound: 22; BAY-85-3934
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Inhibition of recombinant human HIF-PHD2 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
Inhibition of recombinant human HIF-PHD2 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
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10.1039/C6MD00240D |
| Sf9 | IC50 |
0.45 μM
Compound: 22; BAY-85-3934
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Inhibition of recombinant human HIF-PHD3 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
Inhibition of recombinant human HIF-PHD3 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
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10.1039/C6MD00240D |
| Sf9 | IC50 |
0.48 μM
Compound: 22; BAY-85-3934
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Inhibition of recombinant human HIF-PHD1 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
Inhibition of recombinant human HIF-PHD1 expressed in insect Sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate after 60 mins by DELFIA
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10.1039/C6MD00240D |
In Vitro
Molidustat sodium (5 μM; 20 min) is sufficient to induce detectable levels of HIF-1α in HeLa cells. In a cell reporter assay, Molidustat sodium induces expression of a firefly luciferase reporter gene under the control of a hypoxia response element promoter with a mean (± SD) EC50 of 8.4 μM (n=4)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Molidustat sodium (0.5-10 mg/kg; orally; five times weekly) can normalize the blood pressure in rat models of chronic kidney disease (CKD) and effectively alleviate renal anemia in rats with impaired renal function[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1375799-59-9
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분자량 336.28
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화학식 C13H13N8NaO2
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SMILES
[Na]OC1=C(N2N=NC=C2)C=NN1C3=NC=NC(N4CCOCC4)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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Immunity
The transcriptional repressor Fli1 inhibits proteostasis during nutrient stress to limit NK cell persistence in solid tumors. [Abstract]2026 Feb 18:S1074-7613(26)00035-X. PMID: 41713422 -
Cell Rep
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells. [Abstract]2021 Apr 20;35(3):109020. PMID: 33852916 -
iScience
2021 Sep 25;24(10):103170. PMID: 34646996 -
Microb Pathog
Baicalin inhibits macrophage glycolysis and succinate-driven HIF-1α signaling by targeting PKM2 to alleviate RSV-induced inflammation. [Abstract]2026 Apr:213:108291. PMID: 41544903 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569 -
Drug Test Anal
Simultaneous detection of three hypoxia-inducible factor stabilizers-molidustat, roxadustat, and vadadustat-in multiple keratinized matrices and its application in a doping context. [Abstract]2025 May;17(5):647-654. PMID: 38992954
Molidustat sodium purchased from MedChemExpress. Usage Cited in: Drug Test Anal. 2025 May;17(5):647-654. [Abstract]
Beard hair chromatogram. Molidustat concentration is 55 pg/mg. From bottom to top: Transition for internal standard testosterone-d3 (292.24 > 96.99) and two transitions of molidustat (315.0 > 137.10 and 315.10 > 207.00).
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Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135
Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
Effects of adaptaquin (10 mM) and Molidustat (10 mM) on Fe-8HQ (15 mM, 14 h)-induced LDH release in AML 12 cells.
Molidustat sodium purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
Morphology of HT-1080 cells treated with Fe-8HQ (10 mM, 8 h) ± adaptaquin (10 mM) or Molidustat (10 mM).
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순도&문서
References
[1]. Flamme I, et al. Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One. 2014 Nov 13;9(11):e111838. [Content Brief]
[2]. Yamamoto H,et al. Molidustat for Renal Anemia in Nondialysis Patients Previously Treated with Erythropoiesis-Stimulating Agents: A Randomized, Open-Label, Phase 3 Study. Am J Nephrol. 2021;52(10-11):884-893. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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