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Cat. No.: HY-179705

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MOR agonist-5

MOR agonist-5 is a selective and potent mu-opioid receptor (MOR) agonist with an EC₅₀ of 0.25 nM. MOR agonist-5 shows an EC₅₀ of 10 nM for DOR and >10000 nM for KOR and NOR. MOR agonist-5 exerts significant antinociceptive activity. MOR agonist-5 can be used for the research of pain.

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CAS No.: 3085132-31-3
화학식: C₂₂H₂₇N₃O
분자량:349.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MOR agonist-5 Chemical Structure

CAS No.: 3085132-31-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

μ Opioid Receptor/MOR

0.25 nM (EC₅₀)

δ Opioid Receptor/DOR

10 nM (EC₅₀)

κ Opioid Receptor/KOR

>10000 nM (EC₅₀)

NOP Receptor/ORL1

>10000 nM (EC₅₀)

All Opioid Receptor Isoforms :

In Vitro

MOR agonist-5 (Compound 13) demonstrates weak recruitment of β-arrestin2 with pEC₅₀of 7.8^[1]. 
MOR agonist-5 shows an EC₅₀ of 10 nM for DOR and >10000 nM for KOR and NOR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MOR agonist-5 (Compound 13) (i.p.) exerts significant antinociceptive activity, with a ED₅₀ of 0.6581 mg/kg in B6129/F1 hybrid mice with hot plate test and its antinociceptive effect is completely antagonized by Naloxone (HY-17417A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3085132-31-3
분자량 349.47
화학식 C₂₂H₂₇N₃O
SMILES

NC(C1=CC(N2[C@H]3CC[C@@H]2CN(CCCC4=CC=CC=C4)C3)=CC=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Trivedi RR, et al. N-(3-Hydroxyphenyl)-3,8-diazabicyclooctanes as opioid receptors probes. 1. Investigation of the phenolic hydroxyl group. Eur J Med Chem. 2025;298:117991. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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