country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-12476

Copy Link Print Information

SAR156497

SAR156497 (compound 47) is an Aurora inhibitor, with IC50 values of 0.6 nM and 1 nM for Aurora A and Aurora B, respectively. SAR156497 can also inhibit PDE3, with IC₅₀ value of 4 μM. SAR156497 can be used in anticancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1256137-14-0
화학식: C₂₇H₂₄N₄O₄
분자량:468.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SAR156497 Chemical Structure

CAS No.: 1256137-14-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

PDE3

4 μM (IC₅₀)

Aurora A

0.6 nM (IC₅₀)

Aurora B

1 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

All Aurora Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	3.714 μM Compound: SAR156497	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HEK293	IC₅₀	5.864 μM Compound: SAR156497	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	0.00611 μM Compound: SAR156497	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]
HeLa	IC₅₀	67 nM Compound: 47	Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis Antiproliferative activity against human HeLa cells assessed as 14C-thymidine incorporation by Micro-Beta radioactivity counting analysis	[PMID: 25369539]
PBMC	IC₅₀	>10 μM Compound: 47	Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay Cytotoxicity against human hematological tumor PBMC assessed as viability after 96 hrs by MTS assay	[PMID: 25369539]
PC-3	IC₅₀	12.58 μM Compound: SAR156497	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay	[PMID: 28818446]

Chemical Information

CAS No. 1256137-14-0
분자량 468.50
화학식 C₂₇H₂₄N₄O₄
SMILES

O=C1C([C@@H](C2=CC(OC3=NC4=CC=CC=C4N3)=CC=C2)C5=CN6)=C(CCC1)NC5=C6C(OCC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Carry JC, et al. SAR156497, an exquisitely selective inhibitor of aurora kinases. J Med Chem. 2015 Jan 8;58(1):362-75. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SAR156497

Alisertib

Barasertib

Barasertib-HQPA

Reversine

Tozasertib

MK-5108

GSK-1070916

ZM-447439

Hesperadin

AMG 900

LY3295668

MLN8054

All Phosphodiesterase (PDE) Isoforms

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

SAR156497

Alisertib

Barasertib

Barasertib-HQPA

Reversine

Tozasertib

MK-5108

GSK-1070916

ZM-447439

Hesperadin

AMG 900

LY3295668

MLN8054

All Phosphodiesterase (PDE) Isoforms

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SAR156497 Related Classifications

HY-12476 Related Classifications

Bioz