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Streptozotocin

(Synonyms: Streptozocin; NSC-85998; U 9889)
150 Cited Publications
고객리뷰

Based on 150 publication(s) in Google Scholar

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells.

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  • Purity: 99.13%
  • CAS No.: 18883-66-4
  • 화학식: C8H15N3O7
  • 분자량:265.22
  • 보관:

    -20°C, sealed storage, away from moisture and light

    * The compound is unstable in solutions, freshly prepared is recommended.

  • Streptozotocin Chemical Structure
    Streptozotocin Chemical Structure
  • Experimental Validation Results for Streptozotocin
  • Experimental Validation Results for Streptozotocin
  • Experimental Validation Results for Streptozotocin
  • Experimental Validation Results for Streptozotocin
  • Experimental Validation Results for Streptozotocin
CAS No.: 18883-66-4
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  • Streptozotocin Chemical Structure
    Streptozotocin Chemical Structure
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    Streptozotocin purchased from MedChemExpress. Usage Cited in: Cell Metab. 2025 Sep 2;37(9):1907-1925.e14. [Abstract]

    Customer Validation
     Mice were fed a dietconsisting of one-third high-fat feed and two-thirds regular feed for 2 days, followed by a diet consisting of half high-fat feed and half regular feed for another 2 days. Finally, the mice were fed a diet consisting entirely of high-fat feed. After 6 weeks of continuous high-fat feed, Streptozotocin (STZ) (40 mg/kg, i.p., 5 consecutive days) was used to induce T2DM (DM-KPC). H&E and IHC staining of pancreatic tissues.

  • 1/16

    Streptozotocin purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Oct 21;19(41):36813-36825. [Abstract]

    Customer Validation
     Type I diabetic mouse models was induced by intraperitoneal injection of 50 mg/kg Streptozotocin (STZ) daily for 7 days in male C57BL/6 mice (8 weeks old). Two weeks after STZ injection, mice with blood glucose levels exceeding 16.8 mmol/L were considered diabetic. Full-thickness skin wounds (10 mm in diameter) were created on the dorsum. POMHH promotes diabetic wounds healing by remodeling the wound microenvironment.

  • 1/16

    Streptozotocin purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Oct 21;19(41):36813-36825. [Abstract]

    Customer Validation
     Type I diabetic mouse models was induced by intraperitoneal injection of 50 mg/kg Streptozotocin (STZ) daily for 7 days in male C57BL/6 mice (8 weeks old). Two weeks after STZ injection, mice with blood glucose levels exceeding 16.8 mmol/L were considered diabetic. Full-thickness skin wounds (10 mm in diameter) were created on the dorsum. POMHH promotes diabetic wounds healing by remodeling the wound microenvironment

  • 1/16

    Streptozotocin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2021 Jan;5(1):53-63. [Abstract]

    Customer Validation
     Streptozotocin (STZ) was administered intra-peritoneally to each rat at a dose of 65 mg/kg. Water containing 10% sucrose was given to rats for 24 hours after injection with STZ to prevent hypoglycemia. RT-ELISA measurement of in vivo glucose concentrations over 30-50 mins in diabetic rats.

  • 1/16

    Streptozotocin purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2020 May;4(5):507-517. [Abstract]

    Customer Validation
     Male Sprague Dawley rats 160-230 g (8-10 weeks) were fasted 6-8 hours prior to treatment with Streptozotocin (STZ) (65 mg/kg, i.p.). Rats were provided with water containing 10% sucrose for 24 hours after injection with STZ. Blood glucose levels were tested for hyperglycemia daily. Fasted diabetic male rats received subcutaneous administration of different therapies.

  • Streptozotocin