Streptozotocin-Induced Diabetic Models in Mice and Rats

  • Curr Protoc Pharmacol. 2015 Sep 1:70:5.47.1-5.47.20. doi: 10.1002/0471141755.ph0547s70.
Brian L Furman  1
Affiliations
  • 1. Strathclyde Institute of Pharmacy & Biomedical Sciences, Glasgow, Scotland, United Kingdom.
PMID: 26331889 DOI: 10.1002/0471141755.ph0547s70
Abstract

Streptozotocin (STZ) is an Antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced Insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These Animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.

Keywords
high-fat; hyperglycemia; insulin deficiency; insulin resistance; insulitis; mouse or rat; nicotinamide; streptozotocin; type 1 diabetes mellitus; type 2 diabetes mellitus.
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