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Cat. No.: HY-143436

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TNIK-IN-4

TNIK-IN-4 is a potent TNIK inhibitor with IC₅₀ of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116.

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CAS No.: 2754266-04-9
화학식: C₂₀H₁₆FN₃O₃
분자량:365.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

TNIK-IN-4 Chemical Structure

CAS No.: 2754266-04-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocol (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TNIK-IN-4 is a potent TNIK inhibitor with IC₅₀ of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116^[1].

IC₅₀ & Target

IC₅₀: 0.61 μM (TNIK)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	36.423 μM Compound: 5a	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35447345]

In Vitro

TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC₅₀ of 36.423 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Proliferation Assay

View Protocol

Cell Line:

HCT116 cells^[1]
Concentration:

0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM
Incubation Time:

72 hours
Result:

Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC₅₀ of 36.423 μM.

Chemical Information

CAS No. 2754266-04-9
분자량 365.36
화학식 C₂₀H₁₆FN₃O₃
SMILES

O=C1OC2=CC(C3=CC(OC)=C(N)N=C3)=CC=C2N1CC4=CC=C(F)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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