2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. Mal-PEG8-Phe-Lys-PAB-Exatecan TFA

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA 

Cat. No.: HY-148380A Purity: 98.44%
COA Handling Instructions

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Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is a agent-linker conjugate for ADC, composed of degradable linker Mal-PEG8-Phe-Lys-PAB and toxin molecule Exatecan (HY-13631).

For research use only. We do not sell to patients.

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA Chemical Structure

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2350 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Mal-PEG8-Phe-Lys-PAB-Exatecan TFA:

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mal-PEG8-Phe-Lys-PAB-Exatecan TFA is a agent-linker conjugate for ADC, composed of degradable linker Mal-PEG8-Phe-Lys-PAB and toxin molecule Exatecan (HY-13631)[1].

IC50 & Target

Camptothecins

 

Molecular Weight

1548.58

Formula

C75H93F4N9O22
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(NC(C=C3)=CC=C3COC(N[C@@H]4C5=C6C(C(N7C6)=CC([C@](O)(C(OC8)=O)CC)=C8C7=O)=NC9=CC(F)=C(C)C(CC4)=C95)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (64.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6458 mL 3.2288 mL 6.4575 mL
5 mM 0.1292 mL 0.6458 mL 1.2915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6458 mL 3.2288 mL 6.4575 mL 16.1438 mL
5 mM 0.1292 mL 0.6458 mL 1.2915 mL 3.2288 mL
10 mM 0.0646 mL 0.3229 mL 0.6458 mL 1.6144 mL
15 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
20 mM 0.0323 mL 0.1614 mL 0.3229 mL 0.8072 mL
25 mM 0.0258 mL 0.1292 mL 0.2583 mL 0.6458 mL
30 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5381 mL
40 mM 0.0161 mL 0.0807 mL 0.1614 mL 0.4036 mL
50 mM 0.0129 mL 0.0646 mL 0.1292 mL 0.3229 mL
60 mM 0.0108 mL 0.0538 mL 0.1076 mL 0.2691 mL
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Mal-PEG8-Phe-Lys-PAB-Exatecan TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-PEG8-Phe-Lys-PAB-ExatecanDrug-Linker Conjugates for ADCTopoisomeraseExatecancancerADCInhibitorinhibitorinhibit

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