2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-4

MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease.

For research use only. We do not sell to patients.

MAO-B-IN-4 Chemical Structure

MAO-B-IN-4 Chemical Structure

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MAO-B-IN-4 Related Antibodies

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Description

MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease[1].

In Vitro

MAO-B-IN-4 (0.25 μM 24 h exposure to 0.5 μM DOX) displays a significant glioprotective effect in a model of cultured astrocytes [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-4 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 0.1-100 µM
Incubation Time: 72 h
Result: Showed no effect on the viability of the cells after 24 hours of exposure.
In Vivo

MAO-B-IN-4 (1 and 3 mg/kg, p.o., 2 h) can prevent scopolamine-induced short-term memory impairment[1].
MAO-B-IN-4 (0.312-2.5 mg/kg, i.p., 1 h) exhibits antidepressant-like properties in mice in the forced swim test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats treated with anticholinergic scopolamine[1]
Dosage: 1 and 3 mg/kg
Administration: Oral administration; 2h before the experiment
Result: Orally 2 h before the acquisition trial prevented scopolamine-induced short-term memory deficits
Animal Model: Mice models[1]p>
Dosage: 0.312-2.5 mg/kg
Administration: Intraperitoneal injection; 1h
Result: Resulted a similar effect with antidepressant S-citalopram (HY-14258) under the dose of 0.625 mg/kg and 1.25 mg/kg, respecively.
Molecular Weight

411.87

Formula

C23H20ClF2N3
SMILES

FC1(CCN(CC1)C2=NC3=CC=CC=C3C4=C2C=CN4CC5=CC(Cl)=CC=C5)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-4Monoamine OxidaseMAOAlzheimer's diseaseGliaCognitionFluorinated compoundsInhibitorinhibitorinhibit

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