MAO-B-IN-4
MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC50 of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 3037516-37-0
- Formula: C23H20ClF2N3
- Molecular Weight:411.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MAO-B-IN-4 (0.25 μM 24 h exposure to 0.5 μM DOX) displays a significant glioprotective effect in a model of cultured astrocytes [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:0.1-100 µM
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Incubation Time:72 h
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Result:Showed no effect on the viability of the cells after 24 hours of exposure.
MAO-B-IN-4 (0.312-2.5 mg/kg, i.p., 1 h) exhibits antidepressant-like properties in mice in the forced swim test[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats treated with anticholinergic scopolamine[1]
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Dosage:1 and 3 mg/kg
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Administration:Oral administration; 2h before the experiment
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Result:Orally 2 h before the acquisition trial prevented scopolamine-induced short-term memory deficits
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Animal Model:Mice models[1]p>
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Dosage:0.312-2.5 mg/kg
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Administration:Intraperitoneal injection; 1h
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Result:Resulted a similar effect with antidepressant S-citalopram (HY-14258) under the dose of 0.625 mg/kg and 1.25 mg/kg, respecively.
Chemical Information
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CAS No. 3037516-37-0
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Molecular Weight 411.87
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Formula C23H20ClF2N3
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SMILES
FC1(CCN(CC1)C2=NC3=CC=CC=C3C4=C2C=CN4CC5=CC(Cl)=CC=C5)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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