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Art. -Nr.: HY-143330

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MAO-B-IN-4

MAO-B-IN-4 (Compound 26) is an orally active and reversible MAO-B inhibitor with an IC₅₀ of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease.

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CAS. Nr.: 3037516-37-0
Formel: C₂₃H₂₀ClF₂N₃
Molecular Weight:411.87

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

MAO-B-IN-4 Chemical Structure

CAS. Nr.: 3037516-37-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
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Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen :

MAO-A
MAO-B

In Vitro

MAO-B-IN-4 (0.25 μM 24 h exposure to 0.5 μM DOX) displays a significant glioprotective effect in a model of cultured astrocytes ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 cells
Concentration:

0.1-100 µM
Incubation Time:

72 h
Result:

Showed no effect on the viability of the cells after 24 hours of exposure.

In Vivo

MAO-B-IN-4 (1 and 3 mg/kg, p.o., 2 h) can prevent scopolamine-induced short-term memory impairment^[1].
MAO-B-IN-4 (0.312-2.5 mg/kg, i.p., 1 h) exhibits antidepressant-like properties in mice in the forced swim test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats treated with anticholinergic scopolamine^[1]
Dosage:

1 and 3 mg/kg
Administration:

Oral administration; 2h before the experiment
Result:

Orally 2 h before the acquisition trial prevented scopolamine-induced short-term memory deficits

Animal Model:

Mice models^[1]p>
Dosage:

0.312-2.5 mg/kg
Administration:

Intraperitoneal injection; 1h
Result:

Resulted a similar effect with antidepressant S-citalopram (HY-14258) under the dose of 0.625 mg/kg and 1.25 mg/kg, respecively.

Chemical Information

CAS. Nr. 3037516-37-0
Molecular Weight 411.87
Formel C₂₃H₂₀ClF₂N₃
SMILES

FC1(CCN(CC1)C2=NC3=CC=CC=C3C4=C2C=CN4CC5=CC(Cl)=CC=C5)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Grychowska K, et al. Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem. 2022 Jun 5;236:114329. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MAO-B-IN-4

Alle Monoamine Oxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MAO-B-IN-4 Related Classifications

HY-143330 Related Classifications