Methionine sulfoximine
Based on 2 publication(s) in Google Scholar
Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 1982-67-8
- Formula: C5H12N2O3S
- Molecular Weight:180.23
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Metabolism/Protease Compound Library
HY-L012
-
Anti-Cancer Metabolism Compound Library
HY-L083
-
Human Metabolite Library
HY-L123
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Natural Product Diversity Scaffold Library
HY-L245
Publications Citing Use of MedChemExpress (MCE) Methionine sulfoximine
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Chemical Information
-
CAS No. 1982-67-8
-
Appearance Solid
-
Molecular Weight 180.23
-
Formula C5H12N2O3S
-
Color White to off-white
-
SMILES
CS(=N)(=O)CCC(C(=O)O)N
-
Synonyms
2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Adv Sci (Weinh)
Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress-Induced Depression in Male Mice. [Abstract]2025 Dec 12:e13438. PMID: 41387185 -
Drug Dev Res
Inhibition of Glutathione Pathway by Oleanolic Acid via PSAT1 Leads to Ferroptosis in Colorectal Cancer. [Abstract]2025 May;86(3):e70097. PMID: 40320855
Solvent & Solubility
H2O : 50 mg/mL (277.42 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.5485 mL | 27.7423 mL | 55.4847 mL | 138.7116 mL |
| 5 mM | 1.1097 mL | 5.5485 mL | 11.0969 mL | 27.7423 mL | |
| 10 mM | 0.5548 mL | 2.7742 mL | 5.5485 mL | 13.8712 mL | |
| 15 mM | 0.3699 mL | 1.8495 mL | 3.6990 mL | 9.2474 mL | |
| 20 mM | 0.2774 mL | 1.3871 mL | 2.7742 mL | 6.9356 mL | |
| 25 mM | 0.2219 mL | 1.1097 mL | 2.2194 mL | 5.5485 mL | |
| 30 mM | 0.1849 mL | 0.9247 mL | 1.8495 mL | 4.6237 mL | |
| 40 mM | 0.1387 mL | 0.6936 mL | 1.3871 mL | 3.4678 mL | |
| 50 mM | 0.1110 mL | 0.5548 mL | 1.1097 mL | 2.7742 mL | |
| 60 mM | 0.0925 mL | 0.4624 mL | 0.9247 mL | 2.3119 mL | |
| 80 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7339 mL | |
| 100 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3871 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Methionine sulfoximine Related Classifications
HY-W338140 Related Classifications
Powered by Bioz