1982-67-8
1982-67-8
Chemical Structure
Methionine sulfoximine
Synonym(s): 2-Amino-4-(S-methylsulfonimidoyl)butanoic acid
- CAS 番号: 1982-67-8
- Formula:C5H12N2O3S
- Molecular Weight:180.23
IUPAC Name: 2-amino-4-(S-methylsulfonimidoyl)butanoic acid
InChIKey: SXTAYKAGBXMACB-UHFFFAOYSA-N
SMILES: CS(=N)(=O)CCC(C(=O)O)N
Biological Activity: Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Methionine sulfoximine | 99.83% | Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential. | ||||||||||||||||||||
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L-Buthionine-(S,R)-sulfoximine | 99.95% | L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. | ||||||||||||||||||||
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DL-Buthionine-(S,R)-sulfoximine (Standard) | ≥98% | DL-Buthionine-(S,R)-sulfoximine (Standard) is the analytical standard of DL-Buthionine-(S,R)-sulfoximine. This product is intended for research and analytical applications. DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis. | ||||||||||||||||||||
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D-Methionine sulfoxide | 98.74% | D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing. | ||||||||||||||||||||
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L-Homocysteic acid | 98.0% | L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders. | ||||||||||||||||||||
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L-Methionine-DL-sulfoximine | 98.0% | L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS). | ||||||||||||||||||||
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Methionine sulfoxide (Standard) | ≥98% | Methionine sulfoxide (Standard) is the analytical standard of Methionine sulfoxide. This product is intended for research and analytical applications. Methionine sulfoxide is an oxidation product of methionine with reactive oxygen species and can be regarded as a biomarker of oxidative stress in vivo. | ||||||||||||||||||||
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L-Methionine sulfoxide (Standard) | 99.53% | L-Methionine sulfoxide is an orally active oxidation product of Methionine (HY-N0326). L-Methionine sulfoxide can be partially converted into Methionine in the body and participate in the synthesis of glutathione in the liver. L-Methionine sulfoxide provides the body with sulfur activity and can participate in the synthesis of proteins and sulfur-containing compounds. | ||||||||||||||||||||
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2-amino-4-sulfobutanoic acid | 98.0% | 2-amino-4-sulfobutanoic acid is an alanine derivative. | ||||||||||||||||||||
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L-Methionine sulfone | 99.95% | L-Methionine sulfone is a sulfonic acid derivative of L-Methionine (HY-N0326). L-Methionine in the presence of a number of oxidizing systems is readily converted to L-Methionine sulfone. | ||||||||||||||||||||
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DL-Methionine Sulfone | 99.55% | DL-Methionine Sulfone is a Methionine (HY-13694) derivative. | ||||||||||||||||||||
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