Metoprolol Hydrochloride
Based on 11 publication(s) in Google Scholar
Metoprolol Hydrochloride is an orally active and selective β1-adrenoceptor antagonist. Metoprolol Hydrochloride exhibits anti-inflammatory, antitumor, and anti-angiogenic properties.
For research use only. We do not sell to patients.
- CAS No.: 56392-18-8
- Formula: C15H26ClNO3
- Molecular Weight:303.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Metoprolol Hydrochloride
More- Emerg Contam. 2026 Feb 23.
- J Intern Med. 2024 Sep;296(3):291-297. [Abstract]
- Int J Mol Sci. 2026 Apr 15;27(8):3523. [Abstract]
- Int Immunopharmacol. 2024 Oct 25:140:112894. [Abstract]
- J Pharm Biomed Anal. 2021 Feb 20:195:113870. [Abstract]
- Biochem Biophys Res Commun. 2025 Oct 30:786:152756. [Abstract]
- J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 1:1227:123804. [Abstract]
- SSRN. 2024 May 30.
- Environ Toxicol. 2024 Mar;39(3):1682-1699. [Abstract]
- Preprints. 2023 Jun 19.
- Chemosphere. 2019 Jun:225:378-387. [Abstract]
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Others
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Bio/Physico-chemical Assay
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IF
All Adrenergic Receptor Isoforms
More
Biological Activity
Chemical Information
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CAS No. 56392-18-8
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Molecular Weight 303.82
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Formula C15H26ClNO3
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SMILES
OC(CNC(C)C)COC1=CC=C(CCOC)C=C1.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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J Intern Med
SARS-CoV-2 spike protein acts as a β-adrenergic receptor agonist: A potential mechanism for cardiac sequelae of long COVID. [Abstract]2024 Sep;296(3):291-297. PMID: 39073192
Metoprolol Hydrochloride purchased from MedChemExpress. Usage Cited in: J Intern Med. 2024 Sep;296(3):291-297. [Abstract]
Selective blockers Metoprolol (METO; β1-AR blocker; 10 µmol/L) and ICI118551 (ICI; β2-AR blocker; 10 µmol/L) were used to explore the interactions of the spike protein with β1-AR and β2-AR, respectively.
Metoprolol Hydrochloride purchased from MedChemExpress. Usage Cited in: J Intern Med. 2024 Sep;296(3):291-297. [Abstract]
cAMP accumulation in NMCMs treated with ISO (1 µmol/L) and the spike trimer (10 nmol/L) with or without pretreatment with Metoprolol (10 µmol/L) and ICI118551 (10 µmol/L).
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Int J Mol Sci
N- p- trans-Coumaroyltyramine Improves Myocardial Ischemia-Reperfusion Injury: From Cellular Protection to Animal Model Validation and the Discovery of the Target Tcap. [Abstract]2026 Apr 15;27(8):3523. PMID: 42074166 -
Int Immunopharmacol
Baricitinib alleviates cardiac fibrosis and inflammation induced by chronic sympathetic activation. [Abstract]2024 Oct 25:140:112894. PMID: 39126736 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569 -
Biochem Biophys Res Commun
Dual-cardiotoxicity evaluation of torsadogenic risk drugs using human iPSC-derived cardiomyocytes. [Abstract]2025 Oct 30:786:152756. PMID: 41043280 -
J Chromatogr B Analyt Technol Biomed Life Sci
High-throughput screening of LogD by using a sample pooling approach based on the traditional shake flask method. [Abstract]2023 Jul 1:1227:123804. PMID: 37393793 -
Metoprolol Hydrochloride purchased from MedChemExpress. Usage Cited in: SSRN. 2024 May 30.
Quantification of immunofluorescence staining of phosphorylated-GSK3β in NRCFs. The ratio of phosphorylated protein to total protein reflects the activation of signaling pathways. NRCFs were starved for 24h. Mig and Metoprolol (Met: 10 μM) were added ahead for 1h, then ISO was added for 24h. Met was used as positive control.
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Environ Toxicol
Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor. [Abstract]2024 Mar;39(3):1682-1699. PMID: 38041472 -
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Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Purity & Documentation
References
[1]. Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783. [Content Brief]
[2]. Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547(2):195-201. [Content Brief]
[3]. Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18(2):161-5 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)